Disorder "Cervical Cancer"
Found 13 records
Disorder information
Disorder name:
Cervical Cancer
Disoder ID:
OMIM entry:
Synonyms:
cervical neoplasm,cervix cancer,cervix uteri cancer,neoplasm of uterine cervix,tumor of the Cervix Uteri,uterine cervical neoplasm
Definition:
A female reproductive organ cancer that is located_in the cervix.
Modifier statisitcs
Record:
13
Gene:
4
Variant:
9
Reference:
3
Effect type:
Expressivity(13)
Modifier effect:
Risk factor(13)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| Haplotype | Haplotype:(TLR4:rs1927911,rs10759931) | Expressivity | Risk factor | OR=0.6,95% CI: 0.38-0.95; P=0.0272 | The TLR4 haplotype GCA (OR, 0.6 [95% CI, 0.38-0.95]; P=0.0272) and TLR9 haplotype GTA (OR, 1.99 [95% CI, 1.14-3.48]; P=0.014) were found to be associated with decreased and increased risk of cervicitis respectivelymore | more |
| Haplotype:(TLR4:rs352139,rs187084) | Expressivity | Risk factor | OR=1.99, 95% CI: 1.14-3.48; P=0.014 | The TLR4 haplotype GCA (OR, 0.6 [95% CI, 0.38-0.95]; P=0.0272) and TLR9 haplotype GTA (OR, 1.99 [95% CI, 1.14-3.48]; P=0.014) were found to be associated with decreased and increased risk of cervicitis respectivelymore | more | |
| EPCAM | EPCAM:c.344T>C(p.Met115Thr) | Expressivity | Risk factor | CT: OR=1.72; 95% CI: 1.33-2.22; TT: OR=1.96; 95% CI: 1.01-3.81 | CT genotype had a significantly increased risk of Cervical Cancer (Crude OR=1.70; 95% CI = 1.33-2.20; adjusted OR=1.72; 95% CI = 1.33-2.22), the TT carriers had a further increased risk of Cervical Cancer (Crude OR=1.94; 95% CI = 1.01-3.72; adjusted OR=1.96; 95%CI = 1.01-3.81)more | more |