Disorder "Chronic Kidney Disease"
Found 2 records
Disorder information
Disorder name:
Chronic Kidney Disease
Disoder ID:
Synonyms:
CKD,CRF,chronic kidney failure,chronic renal disease,chronic renal failure syndrome,renal failure - chronic
Definition:
Functional anomaly of the kidney persisting for at least three months.
Modifier statisitcs
Record:
2
Gene:
2
Variant:
2
Reference:
2
Effect type:
Expressivity(2)
Modifier effect:
Altered risk of CKD(1)
,Altered severity(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| REN | REN:c.493-131A>C | Expressivity | Altered risk of CKD | OR=4.80; 95 % CI:1.30-17.82; P=0.019 | The rs1464816 polymorphism in REN is associated with CKD progression in ADPKD.more | more |
| ACE | ACE:c.1665T>C(p.Phe555Phe) | Expressivity | Altered severity | Assessment of genotype–phenotype associations | ACE rs4362 contributed to the advancement of CKD.more | more |
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