PhenoModifier-Gene Detail

Gene "REN"

Found 1 record

Gene information

Gene symbol:

REN

See related:

Ensembl: ENSG00000143839, Gene ID: 5972

Additive variants :

Detected

Genetic interaction partners

Confidence	Stringent (ε>0.16 or ε<-0.12)	Intermediate (-0.16≤ε≤-0.08 or 0.08≤ε≤0.16)	Lenient (\|ε\|<0.08)
Positive interactions	SMARCB1 RPL6 XRCC3 EEF2 CORO2B PEX13 PSAT1 SIN3A TTC31 GCLC GPT PEX10 BCAT1 SIRT4 FMO5 FKBP1A ADHFE1 SLC13A4 MOV10 UBE2N PEX14 MAN1A2 PEX1 SUCO HELLS RPL27 RPL14 HAAO GK5 RMND5B MTO1 GAPDH GPD1L ZDHHC6 RFX4 LIPT2 PAQR3 ACOX3 RPL15 USP35 MAPKAPK5 FHIT RPS24 DOT1L ARHGDIB ATM RPLP2 GUF1 RPS6KA1 FIGNL2 TXNL1 CLPB ABHD5 PSPH USP35 DENR METTL11B ARHGEF2 HSPA13 VDAC2 PIAS1 CHIA WDR76 show allhide
Negative interactions	RPS25 SLC25A26 VPS41 RPL7A SLC25A21 RRP8 PUM3 COQ2 SAC3D1 COQ7 RPS16 RPSA UBL5 TBK1 RPS6 SC5D ADA PIM3 GSS RTF1 VAT1L RPS7 GEN1 TPT1 ASH1L VPS13D RPSA LSM7 DICER1 MPC2 METTL1 MRTO4 MRE11 METTL14 SDHAF2 RPS11 APEX2 MRS2 WDR59 CSNK2A2 AMD1 REXO5 OVCA2 PDP2 UNC50 RPS16 ELP1 DYNC2H1 HHATL PSMA4 PABPN1 PIGG LSM1 ATP7B CAMKK2 HDAC7 GPD2 USP10 CHMP5 IDH2 RPS18 EPS15 HK2 TSTD1 OLA1 PGAP1 DPP6 TGFBRAP1 NAP1L1 VPS35 ZC3H15 CTSA PLD1 ATP2B1 UCK2 RIT1 ITPA STAM2 RBMX2 ATP13A3 SLC11A2 SLC30A8 APIP FAAH MTHFS PIM3 ECHDC2 PA2G4 UBE4B TVP23B ZNF622 COG6 show allhide

Modifier statisitcs

Record:

Disorder:

Vriant:

Reference:

Effect type:

Expressivity(1)

Modifier effect:

Altered risk of CKD(1)

Detail：

Variant 1:

REN:c.493-131A>C

Gene:

REN

Genomic location:

chr1:204128854

dbSNP ID:

rs1464816

Target disease:

Chronic Kidney Disease(DOID_784)

Effect type:

Expressivity

Modifier effect:

Altered risk of CKD

Evidence:

OR=4.80; 95 % CI:1.30-17.82; P=0.019

Effect:

The rs1464816 polymorphism in REN is associated with CKD progression in ADPKD.

Reference:

PMID26753721

Title:

Renin gene rs1464816 polymorphism contributes to chronic kidney disease progression in ADPKD.

Species studied:

Human

Abstract:

Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder and is a common genetic cause of chronic renal failure in children and adults. The enzyme renin plays a key role in the RAAS cascade and an important role in the development of hypertension and progression of renal disease in ADPKD. The present study is aimed to investigate the potential modifier effect of REN gene polymorphisms on the progression of chronic kidney disease (CKD) in ADPKD.