Disorder "Acute Lymphocytic Leukemia"
Found 6 records
Disorder information
Disorder name:
Acute Lymphocytic Leukemia
Disoder ID:
OMIM entry:
Synonyms:
acute lymphoblastic leukemia
Definition:
A lymphoblastic leukemia that is characterized by over production of lymphoblasts.
Modifier statisitcs
Record:
6
Gene:
4
Variant:
4
Reference:
3
Effect type:
Expressivity(5)
,Penetrance(1)
Modifier effect:
Risk factor(4)
,Altered onset time(1)
,Prevention of disease(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| TP53 | TP53:rs1042522 | Expressivity | Risk factor | OR=2.22, 95% CI: 1.30-3.79 | P53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of common cancers.more | more |
| TP53:rs1042522 | Expressivity | Risk factor | OR=2.9, 95% CI: 1.5-5.6, p=0.002 | TP53 R72P as a possible risk modifier for childhood ALL and the association of MDM2 with age at onset with sex effect suggests prenatal hormonal programming of childhood ALL susceptibility.more | more | |
| MTHFR | MTHFR:c.A1298C(p.Glu429Ala) | Expressivity | Risk factor | P value =0.001, OR=0.382, 95% CI: 0.222-0.658 | C677T and A1299C Polymorphism as Risk Modifiers of Pediatric Acute Lymphoblastic Leukemiamore | more |
| MDM2 | MDM2:n.-3306A>C | Expressivity | Risk factor | OR=1.49, 95% CI: 0.95-2.53 | P53 72Arg>Pro and MDM2 309T>G polymorphisms contribute to the risk of common cancers.more | more |
| MDM2:n.-3306A>C | Expressivity | Altered onset time | P=0.002 | TP53 R72P as a possible risk modifier for childhood ALL and the association of MDM2 with age at onset with sex effect suggests prenatal hormonal programming of childhood ALL susceptibility.more | more | |
| Haplotype | Haplotype:(MTHFR:677CT,MTHFR:1298AC) | Penetrance | Prevention of disease | (p value=0.002) with 3.65 fold protection (OR=0.273 & 95% CI: 0.155-0.9) compared to 2.6 folds for MTHFR 1298AC alone. | C677T and A1299C Polymorphism as Risk Modifiers of Pediatric Acute Lymphoblastic Leukemiamore | more |
Total 6,Each Page
,Jump To
Page