Gene "CASP10"
Found 5 records
Gene information
Gene symbol:
CASP10
See related:
Ensembl: ENSG00000003400, Gene ID: 843
Additive variants :
Undetected
Genetic interaction partners
No data
Modifier statisitcs
Record:
5 
Disorder:
1 
Vriant:
5 
Reference:
1 
Effect type:
Expressivity(5)  
Modifier effect:
Risk factor(5)  
Details：
  • Variant 1:
    CASP10:rs6435069
    Gene:
    CASP10
    Genomic location:
    dbSNP ID:
    rs6435069
    Target disease:
    Asthma(DOID_2841)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=0.047 
    Effect:
    These data suggest a role for CASP10 as a potential modifier of the asthma phenotype, specifically with measures of airway obstruction and BHR.
    Reference:
    PMID18823309
    Title:
    Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.
    Species studied:
    Human
    Abstract:
    Several chromosomal regions have been identified using family-based linkage analysis to contain genes contributing to the development of asthma and allergic disorders. One of these regions, chromosome 2q32-q33, contains a gene cluster containing CFLAR, CASP10 and CASP8. These genes regulate the extrinsic apoptosis pathway utilized by several types of immune and structural cells that have been implicated in the pathogenesis of asthma.
  • Variant 2:
    CASP10:rs6435068
    Gene:
    CASP10
    Genomic location:
    dbSNP ID:
    rs6435068
    Target disease:
    Asthma(DOID_2841)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=0.026 
    Effect:
    These data suggest a role for CASP10 as a potential modifier of the asthma phenotype, specifically with measures of airway obstruction and BHR.
    Reference:
    PMID18823309
    Title:
    Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.
    Species studied:
    Human
    Abstract:
    Several chromosomal regions have been identified using family-based linkage analysis to contain genes contributing to the development of asthma and allergic disorders. One of these regions, chromosome 2q32-q33, contains a gene cluster containing CFLAR, CASP10 and CASP8. These genes regulate the extrinsic apoptosis pathway utilized by several types of immune and structural cells that have been implicated in the pathogenesis of asthma.
  • Variant 3:
    CASP10:rs13396523
    Gene:
    CASP10
    Genomic location:
    dbSNP ID:
    rs13396523
    Target disease:
    Asthma(DOID_2841)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=0.014 
    Effect:
    These data suggest a role for CASP10 as a potential modifier of the asthma phenotype, specifically with measures of airway obstruction and BHR.
    Reference:
    PMID18823309
    Title:
    Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.
    Species studied:
    Human
    Abstract:
    Several chromosomal regions have been identified using family-based linkage analysis to contain genes contributing to the development of asthma and allergic disorders. One of these regions, chromosome 2q32-q33, contains a gene cluster containing CFLAR, CASP10 and CASP8. These genes regulate the extrinsic apoptosis pathway utilized by several types of immune and structural cells that have been implicated in the pathogenesis of asthma.
  • Variant 4:
    CASP10:rs10166093
    Gene:
    CASP10
    Genomic location:
    dbSNP ID:
    rs10166093
    Target disease:
    Asthma(DOID_2841)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=0.0033 
    Effect:
    These data suggest a role for CASP10 as a potential modifier of the asthma phenotype, specifically with measures of airway obstruction and BHR.
    Reference:
    PMID18823309
    Title:
    Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.
    Species studied:
    Human
    Abstract:
    Several chromosomal regions have been identified using family-based linkage analysis to contain genes contributing to the development of asthma and allergic disorders. One of these regions, chromosome 2q32-q33, contains a gene cluster containing CFLAR, CASP10 and CASP8. These genes regulate the extrinsic apoptosis pathway utilized by several types of immune and structural cells that have been implicated in the pathogenesis of asthma.
  • Variant 5:
    CASP10:c.922+243C>T
    Gene:
    CASP10
    Genomic location:
    chr2:202073149
    dbSNP ID:
    rs6750157
    Target disease:
    Asthma(DOID_2841)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor 
    Evidence:
    P=0.0009 
    Effect:
    These data suggest a role for CASP10 as a potential modifier of the asthma phenotype, specifically with measures of airway obstruction and BHR.
    Reference:
    PMID18823309
    Title:
    Association of polymorphisms in CASP10 and CASP8 with FEV(1)/FVC and bronchial hyperresponsiveness in ethnically diverse asthmatics.
    Species studied:
    Human
    Abstract:
    Several chromosomal regions have been identified using family-based linkage analysis to contain genes contributing to the development of asthma and allergic disorders. One of these regions, chromosome 2q32-q33, contains a gene cluster containing CFLAR, CASP10 and CASP8. These genes regulate the extrinsic apoptosis pathway utilized by several types of immune and structural cells that have been implicated in the pathogenesis of asthma.