Gene "FBXL7"
Found 1 record
Gene information
Gene symbol:
FBXL7
See related:
Ensembl: ENSG00000183580, Gene ID: 23194
Additive variants :
Detected
Genetic interaction partners
No data
Modifier statisitcs
Record:
1 
Disorder:
1 
Vriant:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Altered response to inhaled corticosteroid(1)  
Detail：
  • Variant 1:
    FBXL7:rs10044254
    Gene:
    FBXL7
    Genomic location:
    chr5:15783596
    dbSNP ID:
    rs10044254
    Target disease:
    Asthma(DOID_2841)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered response to inhaled corticosteroid 
    Evidence:
    P=9.16×10(-8) 
    Effect:
    rs10044254, associated with both decreased expression of FBXL7 and improved symptomatic response to ICSs in 2 independent pediatric cohorts.
    Reference:
    PMID24486069
    Title:
    Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids.
    Species studied:
    Human
    Abstract:
    To date, genome-wide association studies (GWASs) of inhaled corticosteroid (ICS) response in asthmatic patients have focused primarily on lung function and exacerbations.