Gene "FN1"
Found 1 record
Gene information
Gene symbol:
FN1
See related:
Ensembl: ENSG00000115414, Gene ID: 2335
Additive variants :
Undetected
Genetic interaction partners
No data
Modifier statisitcs
Record:
1 
Disorder:
1 
Vriant:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Altered onset time(1)  
Detail：
  • Variant 1:
    FN1:c.1394-310T>C
    Gene:
    FN1
    Genomic location:
    chr2:216287276
    dbSNP ID:
    rs1250249
    Target disease:
    Multiple Sclerosis(DOID_2377)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered onset time 
    Evidence:
    P=0.0002 
    Effect:
    SNP rs1250249 of the FN1 had a dose-dependent effect on age at disease onset
    Reference:
    PMID28473999
    Title:
    Gene variants of adhesion molecules act as modifiers of disease severity in MS.
    Species studied:
    Human
    Abstract:
    To assess the potential effect of variants in genes encoding molecules that are implicated in leukocyte trafficking into the CNS on the clinical phenotype of multiple sclerosis (MS).