PhenoModifier-Gene Detail

Gene "MAPK11"

Found 1 record

Gene information

Gene symbol:

MAPK11

See related:

Ensembl: ENSG00000185386, Gene ID: 5600

Additive variants :

Detected

Genetic interaction partners

Confidence	Stringent (ε>0.16 or ε<-0.12)	Intermediate (-0.16≤ε≤-0.08 or 0.08≤ε≤0.16)	Lenient (\|ε\|<0.08)
Positive interactions	BIN3 RPLP2 POMT2 SIRT2 ZDHHC4 SMARCB1 GRAMD2A CLPB WDR59 GTPBP3 EEF1G COX10 SNAPC4 ZFP42 BOLA3 MOCS3 THNSL1 MGMT TRMT1L RPL29 PEF1 MPC2 IDH3A HHATL RPS24 TGS1 PEX14 RTF1 RPS6KA1 RPL11 LSM1 RBBP5 ATG3 FASN ATM ELP2 RNF19A RRP8 CLPX MIOS MYO7B CHTF18 SLC3A1 TUBA3D DBT ACAA1 TALDO1 ARL14 CHMP5 RPL24 EDF1 PSPH ANKRD55 DGAT1 STK39 ATP2B1 XPOT EP400 PRKG2 ZNF598 SLC25A1 PDPK1 KDM4A RPL35 CHD8 CTU1 RAB5B MAEA MSRB3 GLRX2 TKFC GYG1 ANKEF1 RPS6 TBC1D30 APRT ISG20 show allhide
Negative interactions	CDC73 SRPK2 FA2H SACM1L ARHGAP29 DICER1 PPCDC METTL18 HCFC2 CHN1 PPP6R3 SLC30A8 ATAD2 NF1 SCPEP1 FIGNL2 LEO1 SUB1 TSSK3 ARHGAP11A MRPL36 DDX31 YME1L1 CFDP1 ING3 TRMT44 UBE2D3 MSH2 EPS15 CSNK2B VRK1 GRK7 CYB5RL AP2M1 GAPDH RCOR1 PRKAB1 MAD2L1 DOT1L AIRE WDHD1 EEF1G UBE4B TGFBRAP1 CANX RPL13 MAPKAPK5 BRD1 TIA1 CNDP1 UXS1 SUCLG2 MECOM LSM14B PPIAL4A TREH RHEB MELK SCYL1 ELOVL1 HLTF PNPLA6 TRNAU1AP GYS1 PI4K2A ETFB RBM22 IDH2 SUCO SLC11A2 RNF139 LARP7 show allhide

Modifier statisitcs

Record:

Disorder:

Vriant:

Reference:

Effect type:

Expressivity(1)

Modifier effect:

Risk factor(1)

Detail：

Variant 1:

MAPK11:c.-1628C>T

Gene:

MAPK11

Genomic location:

chr22:50710349

dbSNP ID:

rs2235356

Target disease:

Colorectal Cancer(DOID_9256)

Effect type:

Expressivity

Modifier effect:

Risk factor

Evidence:

OR=1.99; 95% CI: 1.60-2.47; P<0.0001

Effect:

This allelic variant may be a genetic modifier for CRC susceptibility.

Reference:

PMID23946768

Title:

A genetic variation of the p38β promoter region is correlated with an increased risk of sporadic colorectal cancer.

Species studied:

Human

Abstract:

p38 plays a critical role in the proliferation, survival, migration and metastasis of colorectal cancer (CRC) cells. The present study assessed the correlation between a single nucleotide polymorphism (SNP) in the p38β promoter region (rs2235356, -1628A>G) and the predisposition of individuals to sporadic CRC in a case-control study. A genotyping method was developed to detect this SNP, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. A logistic regression analysis was used to determine the odds ratio (OR) and 95% confidence interval (CI). It was revealed that the -1628G variant allele was correlated with an increased risk of CRC (OR, 1.99; 95% CI, 1.60-2.47; P<0.0001). An in silico analysis revealed several transcription factors that either acquired or lost the ability to bind to -1628AA in the p38β promoter region due to the SNP. Therefore, this allelic variant may be a genetic modifier for CRC susceptibility.