PhenoModifier-Gene Detail

Gene "MPO"

Found 1 record

Gene information

Gene symbol:

MPO

See related:

Ensembl: ENSG00000005381, Gene ID: 4353

Additive variants :

Undetected

Genetic interaction partners

No data

Modifier statisitcs

Record:

1

Disorder:

1

Vriant:

1

Reference:

1

Effect type:

Expressivity(1)

Modifier effect:

Altered susceptibility(1)

Detail：

Variant 1:

MPO:c.G-463A

Gene:

MPO

Genomic location:

dbSNP ID:

Target disease:

Sickle Cell Anemia(DOID_10923)

Effect type:

Expressivity

Modifier effect:

Altered susceptibility

Evidence:

P=0.0112

Effect:

Here we present evidence to suggest that a polymorphism (G-463A MPO) in the gene encoding the myeloperoxidase (MPO) enzyme, important for the host defense system, may significantly increase susceptibility to infection in SCA.

Reference:

PMID15996936

Title:

Association of the G-463A myeloperoxidase polymorphism with infection in sickle cell anemia.

Species studied:

Human

Abstract:

Infections constitute a principal cause of morbidity and mortality in sickle cell anemia (SCA). Here we present evidence to suggest that a polymorphism (G-463A MPO) in the gene encoding the myeloperoxidase (MPO) enzyme, important for the host defense system, may significantly increase susceptibility to infection in SCA.