PhenoModifier-Gene Detail

Gene "UBR5"

Found 1 record

Gene information

Gene symbol:

UBR5

See related:

Ensembl: ENSG00000104517, Gene ID: 51366

Additive variants :

Detected

Genetic interaction partners

Confidence	Stringent (ε>0.16 or ε<-0.12)	Intermediate (-0.16≤ε≤-0.08 or 0.08≤ε≤0.16)	Lenient (\|ε\|<0.08)
Positive interactions	RPS8 RPS29 ADA FOXJ3 HSPA4L ELP2 IDH3B ATG3 VPS8 TIA1 VAC14 PDHB OLA1 GGPS1 ALDH16A1 HNRNPM ERCC4 METTL18 VPS13D ROMO1 GPX7 SLC13A4 DPH7 RCOR1 SLC30A8 TMED9 DMXL1 PSMA4 DPH6 ASNS CNDP1 UBE2N WDR6 GAPDH SCAP HHATL RPEL1 PEX1 PEF1 GAPDH TEX261 ADAP2 IDH3A RAD52 GABARAP RBM22 ABHD2 NAPEPLD ZNF622 TSTD1 CERK ALDH1L2 ZDHHC17 AP2M1 SHMT2 TGIF2 LETM1 PPTC7 XRN1 MSRB3 OTUD6A HGH1 PPM1B ALG10B TCF25 EPN3 IDO1 SDHAF2 INPP5E show allhide
Negative interactions	RPL9 RPL23 RPSA RPS11 TRMU RPS16 RPS21 COQ7 RPL13 RPL17-C18orf32 RPL11 RPS6 UBA52 H2AFX RPS3A RPL31 RPS24 RPS23 RPS18 RPS16 RPS7 RPL13A RPS6 RPL35 RPL37A DDX21 RPS10 RBM34 GEN1 HIST2H4B RPS4X RPSA RPL7A FAU RPL14 RPL36 NOLC1 FKBP1A BIN3 WDR59 NCBP2 NFYB RPS29 BUD31 SLC25A26 TGS1 RBKS RPL19 CLIP1 RPS14 ASF1A ABCF3 CTDSPL2 RRP8 FAU RAB6B RPL8 TTF2 PRKAG2 PDCD6IP UCK2 RBBP5 IMPACT HAGHL DENR DBR1 CCNA2 TRIAP1 ARL14 LENG8 RPL37 ATP13A3 WDR45B GCN1 PPCDC ERCC6 GRAMD2A GATA2 PRKCSH GET4 PFDN6 CAPZA2 LIAS ATG7 DBT RNF10 RPL4 SLC35B1 PPAN MLH3 TRNAU1AP DDX11 ABAT PPP6C EEF1G UBXN7 FH ORMDL2 UBE2F-SCLY SRPK2 AIRE UBR3 MAEA CAPZB ALG5 WDR48 GPT ANKEF1 ATXN2 TAPT1 DTD1 SETD6 SCYL2 SIRT2 WRN LYST REXO5 SH3YL1 AP3S2 TST ACSS3 SLC3A1 ATG9B ABCC5 PLD1 RPS6KA1 PSPH SCYL1 show allhide

Modifier statisitcs

Record:

Disorder:

Vriant:

Reference:

Effect type:

Expressivity(1)

Modifier effect:

Altered onset time(1)

Detail：

Variant 1:

UBR5:variant

Gene:

UBR5

Genomic location:

dbSNP ID:

Target disease:

Huntington's Disease(DOID_12858)

Effect type:

Expressivity

Modifier effect:

Altered onset time

Evidence:

From review article

Effect:

Associated with age at disease onset

Reference:

PMID29977663

Title:

Genetic Modifiers in Neurodegeneration.

Species studied:

Human

Abstract:

To review the evidence for genetic modifier effects in the neurodegenerative diseases Huntington's Disease (HD), Frontotemporal Lobar Degeneration (FTLD), Alzheimer's Disease (AD), and Parkinson's Disease (PD).