Variant "IL25:c.424C>A(p.Arg142Arg)"
Search result: 1 record
Variant information
Gene:
IL25 
Variant:
IL25:c.424C>A(p.Arg142Arg) 
Genomic location:
chr14:23844979(hg19) 
HGVS:
SO Term RefSeq
protein_coding NM_022789.3:c.424C>A(p.Arg142Arg)
protein_coding NM_172314.1:c.376C>A(p.Arg126Arg)
protein_coding NM_001288746.1:c.-1482C>A
protein_coding NM_001037288.1:c.-1482C>A
protein_coding NM_001288744.1:c.-1482C>A
protein_coding NM_001288745.1:c.-1482C>A
protein_coding NM_138460.2:c.-1482C>A
show all
dbSNP ID:
rs1124053  
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor and altered severity(1)  
Detail：
  • Target disease:
    Psoriasiform Dermatitis (HP:0003765)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor and altered severity 
    Evidence:
    Severe forms of psoriasis (p=0.010; OR=2.42, 95% CI:1.23-4.76) and presence of arthritis (p=0.032; OR=1.50, 95% CI:1.04-2.18) 
    Effect:
    We identified the IL17RA rs4819554 SNP as a risk factor for PsO. The IL17E rs79877597 SNP was a modifier of the risk for PsO disease severity and PsA.
    Reference:
    PMID26347322
    Title:
    Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and Psoriasis in a Spanish cohort.
    Species studied:
    Human
    Abstract:
    The IL17 pathway plays an important role in the pathogenesis of psoriasis (PsO).