Disorder "Psoriasiform Dermatitis"
Found 5 records
Disorder information
Disorder name:
Psoriasiform Dermatitis
Disoder ID:
Definition:
A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales).
Modifier statisitcs
Record:
5
Gene:
3
Variant:
5
Reference:
2
Effect type:
Expressivity(5)
Modifier effect:
Risk factor(3)
,Altered severity(1)
,Risk factor and altered severity(1)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| TYK2 | TYK2:c.2783C>T(p.Ala928Val) | Expressivity | Risk factor | OR=0.53, P=1.2×10(-9 | Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore | more |
| TYK2:c.2051T>G(p.Ile684Ser) | Expressivity | Risk factor | OR=0.86, P=4.6×10(-7) | Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore | more | |
| TYK2:c.3310C>G(p.Pro1104Ala) | Expressivity | Risk factor | OR=0.66, P=2.3×10(-21) | Reduced risk of rheumatoid arthritis, systemic lupus erythematosusmore | more | |
| IL25 | IL25:c.424C>A(p.Arg142Arg) | Expressivity | Risk factor and altered severity | Severe forms of psoriasis (p=0.010; OR=2.42, 95% CI:1.23-4.76) and presence of arthritis (p=0.032; OR=1.50, 95% CI:1.04-2.18) | We identified the IL17RA rs4819554 SNP as a risk factor for PsO. The IL17E rs79877597 SNP was a modifier of the risk for PsO disease severity and PsA.more | more |
| IL17RA | IL17RA:rs4819554 | Expressivity | Altered severity | OR=1.33, 95% CI:1.05-1.69; p=0.017 | We identified the IL17RA rs4819554 SNP as a risk factor for PsO. The IL17E rs79877597 SNP was a modifier of the risk for PsO disease severity and PsA.more | more |
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