Variant "LTA4H:c.-1400C>T"
Search result: 1 record
Variant information
Gene:
LTA4H 
Variant:
LTA4H:c.-1400C>T 
Genomic location:
chr12:96438553(hg19) 
HGVS:
SO Term RefSeq
protein_coding NM_001256643.1:c.-1400C>T
protein_coding NM_001256644.1:c.-1400C>T
LTA4H-ELK3:n.96438553G>A
dbSNP ID:
rs2660845  
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Altered response to leukotriene modifiers(1)  
Detail：
  • Target disease:
    Asthma (DOID_2841)
    Effect type:
    Expressivity 
    Modifier effect:
    Altered response to leukotriene modifiers 
    Evidence:
    From review article 
    Effect:
    Variants in ALOX5, LTA4H, LTC4S, ABCC1, CYSLTR2, and SLCO2B1 contribute to variability in response to leukotriene modifiers
    Reference:
    PMID19077707
    Title:
    Pharmacogenetics of asthma.
    Species studied:
    Human
    Abstract:
    Patient response to the asthma drug classes, bronchodilators, inhaled corticosteroids and leukotriene modifiers, are characterized by a large degree of heterogeneity, which is attributable in part to genetic variation. Herein, we review and update the pharmacogenetics and pharmaogenomics of common asthma drugs.