Variant "SERPINA3:c.1068+404C>A"
Search result: 1 record
Variant information
Gene:
SERPINA3 
Variant:
SERPINA3:c.1068+404C>A 
Genomic location:
chr14:95089232(hg19) 
HGVS:
SO Term RefSeq
protein_coding NM_001085.4:c.1068+404C>A
dbSNP ID:
rs17091162  
GWAS trait:
no data 
Modifier statisitcs
Record:
1 
Disorder:
1 
Reference:
1 
Effect type:
Expressivity(1)  
Modifier effect:
Risk factor and Altered life span(1)  
Detail：
  • Target disease:
    Pancreatic Cancer (DOID_1793)
    Effect type:
    Expressivity 
    Modifier effect:
    Risk factor and Altered life span 
    Evidence:
    P=10(-4) 
    Effect:
    Significant associations between mutation and overall survival in pancreatic cancer, as well as survival interactions between various genes and radiotherapy and chemotherapy.
    Reference:
    PMID21487324
    Title:
    Genetic effects and modifiers of radiotherapy and chemotherapy on survival in pancreatic cancer.
    Species studied:
    Human
    Abstract:
    Germ-line genetic variation may affect clinical outcomes of cancer patients. We applied a candidate-gene approach to evaluate the effect of putative markers on survival of patients with pancreatic cancer. We also examined gene-radiotherapy and gene-chemotherapy interactions, aiming to explain interindividual differences in treatment outcomes.