Disorder "Pancreatic Cancer"
Found 6 records
Disorder information
Disorder name:
Pancreatic Cancer
Disoder ID:
Synonyms:
pancreatic neoplasm, malignant neoplasm of tail of pancreas, pancreatic tumor, Ca tail of pancreas, Ca head of pancreas, Ca body of pancreas, malignant neoplasm of head of pancreas, pancreas neoplasm, malignant neoplasm of body of pancreas
Definition:
A tumor (abnormal growth of tissue) of the pancreas.
Modifier statisitcs
Record:
6
Gene:
5
Variant:
6
Reference:
3
Effect type:
Expressivity(6)
Modifier effect:
Risk factor(3)
,Risk factor and Altered life span(3)
| Modifier gene | Variant | Effect type | Modifier effect | Evidence | Effect | PubMed ID |
|---|---|---|---|---|---|---|
| XRCC2 | XRCC2:c.563G>A(p.Arg188His) | Expressivity | Risk factor | OR=2.32, 95% CI: (1.25-4.31) | XRCC2 Arg188His polymorphism may be one of the genetic modifiers for smoking-related pancreatic cancermore | more |
| SERPINA3 | SERPINA3:c.1068+404C>A | Expressivity | Risk factor and Altered life span | P=10(-4) | Significant associations between mutation and overall survival in pancreatic cancer, as well as survival interactions between various genes and radiotherapy and chemotherapy.more | more |
| ERCC2 | ERCC2:c.2251A>C(p.Lys751Gln) | Expressivity | Risk factor | The XPD 312asp and 751lys alleles were in linkage disequilibrium (p<0.001; d′=0.64 and d′=0.68 for controls and patients, respectively) | The XPD gene polymorphism could be a genetic risk modifier for smoking-related pancreatic cancer.more | more |
| ERCC2:c.934G>A(p.Asp312Asn) | Expressivity | Risk factor | OR=0.46, 95% CI: 0.24-0.88 | Stratified analyses showed ever smokers carrying the Asn(312)Asn genotype had a significantly reduced risk when compared with those carrying the (312)Asp allele (OR=0.46, 95% confidence interval 0.24-0.88) (P for interaction=0.03).more | more | |
| DPYD | DPYD:c.2623-38806T>C | Expressivity | Risk factor and Altered life span | P=0.0013 | Significant associations between mutation and overall survival in pancreatic cancer, as well as survival interactions between various genes and radiotherapy and chemotherapy.more | more |
| ABCG2 | ABCG2:c.1738-46G>A | Expressivity | Risk factor and Altered life span | P=0.0023 | Significant associations between mutation and overall survival in pancreatic cancer, as well as survival interactions between various genes and radiotherapy and chemotherapy.more | more |
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