Resveratrol

Basic Information

CAS ID: 501-36-0
Molecular Formula: C14H12O3
Molecular Weight: 228.3 g/mol
Monoisotopic Mass: 228.0786 g/mol
Class: Small Molecule
Natural Product: Yes
Other Names: 3,5,4'-Trihydroxy-trans-stilbene | (E)-resveratrol | Resveratrol
Analysis: Drug repositioning mechanism analysis

HO OH OH

Compound Structure and Identifier

InChI: InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+ See All
InChI Key: LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Smiles: Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0671 NAD-dependent protein deacetylase sirtuin-1 activator

Related Fibrosis Property

Reference Record 1

PubMed ID 27129290 Target ID
Uniprot ID Name
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB

Reference Record 2

PubMed ID 25721869 Target ID
Uniprot ID Name
Model vitro,human Fibrosis Disease Scar
Process I
Process II fibroblasts proliferation,cells apoptosis
Process III
Mechanism Targeting TGF-β1 and Smad-2,3,4,7

Reference Record 3

PubMed ID 24356887 Target ID
Uniprot ID Name
Model vitro,mice,rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting sirtuin-1

Reference Record 4

PubMed ID 24152192 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 20651248 Target ID
Uniprot ID Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting Smad3

Reference Record 6

PubMed ID 16343977 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II myofibroblasts prolifertation
Process III
Mechanism

Reference Record 7

PubMed ID 26891083 Target ID T0671
Uniprot ID NAD-dependent protein deacetylase sirtuin-1 Name NAD-dependent protein deacetylase sirtuin-1
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 8

PubMed ID 24939721 Target ID
Uniprot ID Name
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 24782617 Target ID
Uniprot ID Name
Model vitro,rat Fibrosis Disease Intestinal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting SIRT1

Reference Record 10

PubMed ID 24289075 Target ID
Uniprot ID Name
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 23815229 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Keloid
Process I
Process II cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 19373235 Target ID
Uniprot ID Name
Model vitro,mice Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 28447760 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Scar
Process I
Process II fibroblasts proliferation
Process III
Mechanism Targeting mTOR and 70S6K

Reference Record 14

PubMed ID 26891034 Target ID T0671
Uniprot ID NAD-dependent protein deacetylase sirtuin-1 Name NAD-dependent protein deacetylase sirtuin-1
Model vitro,mice Fibrosis Disease Scar
Process I
Process II fibroblasts activation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID NCT02030977 Disease Liver fibrosis
Phase Phase 2,Phase 3 Status Completed
First Received January 9, 2014 Last Verified January 9, 2014
Sponsor Dr Azita Hekmatdoost

Related Link

PubChem: 445154
ChEMBL: CHEMBL165