NAD-dependent protein deacetylase sirtuin-1

Basic Information

Uniprot ID: Q96EB6
Secondary ID: Q2XNF6
Symbol: SIRT1
Other Name: SIR2L1,hSIRT1,Regulatory protein SIR2 homolog 1,SIR2-like protein 1,hSIR2,75SirT1,SirtT1 75 kDa fragment,75SirT1
Class: Epigenetics
Type: anti-fibrotic
Molecular Function: Developmental protein,Hydrolase

Target Classification

Category I Category II Category III
Intracellular Epigenetics Eraser

Related Compound

Target ID Name Interaction
D0013 Resveratrol activator
D0132 SRT1720 activator

Fibrosis Related Property

Reference Record 1

PubMed ID 28532580 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Systemic sclerosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting mTOR pathway

Reference Record 2

PubMed ID 27871879 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II HSC activation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 27524235 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting DLL4

Reference Record 4

PubMed ID 27387128 Compound ID D0132
CAS 1001645-58-4 Name SRT1720
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting miR-34a/SIRT1/p53

Reference Record 5

PubMed ID 27255945 Compound ID D0132
CAS 1001645-58-4 Name SRT1720
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ER stress

Reference Record 6

PubMed ID 26435214 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III
Mechanism

Reference Record 7

PubMed ID 25180292 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism Targeting TGF-β signaling

Reference Record 8

PubMed ID 24356887 Compound ID
CAS Name
Model vitro,mice,rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β/Smad3 pathway

Reference Record 9

PubMed ID 24136919 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 23583181 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting SIRT1/Smad4/β-catenin

Reference Record 11

PubMed ID 20335659 Compound ID D0132
CAS 1001645-58-4 Name SRT1720
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism Targeting COX2

Reference Record 12

PubMed ID 26891083 Compound ID D0013
CAS 501-36-0 Name Resveratrol
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 13

PubMed ID 26891034 Compound ID D0013
CAS 501-36-0 Name Resveratrol
Model vitro,mice Fibrosis Disease Scar
Process I
Process II fibroblasts activation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism