Telmisartan

Basic Information

CAS ID: 144701-48-4
Molecular Formula: C33H30N4O2
Molecular Weight: 514.6 g/mol
Monoisotopic Mass: 514.2369 g/mol
Class: Small Molecule
Natural Product: No
Other Names: BIBR 277 SE | TELMISARTAN | BIBR-277SE | MICARDIS | TOLURA
Analysis: Drug repositioning mechanism analysis

N N O HO N N

Compound Structure and Identifier

InChI: InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39) See All
InChI Key: RMMXLENWKUUMAY-UHFFFAOYSA-N
Smiles: CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)c4ccccc4C(=O)O)c5nc6ccccc6n5C See All
Molfile: Download

Related Target

Target ID Name Interaction
T0118 Type-1 angiotensin II receptor antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID 28656296 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ACE2-Ang-MasR axis

Reference Record 2

PubMed ID 27519769 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro,human,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting PPARδ/STAT3 pathway

Reference Record 3

PubMed ID 26657532 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β 1/Smad signaling

Reference Record 4

PubMed ID 24352213 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 5

PubMed ID 21720156 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting mTOR/S6K1 signaling

Reference Record 6

PubMed ID 18423812 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model human Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 15168334 Target ID
Uniprot ID Name
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 20888384 Target ID
Uniprot ID Name
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Ang II and ET-1

Reference Record 9

PubMed ID 21381899 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 16141465 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 28791353 Target ID
Uniprot ID Name
Model rat Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III
Mechanism Targeting TGF‑β1/Smad3 signaling pathway

Trial Record 1

ClinicalTrial ID NCT02499562 Disease Liver fibrosis
Phase Phase 2 Status Unknown
First Received July 16, 2015 Last Verified July 16, 2015
Sponsor Shanghai Genomics, Inc.

Trial Record 2

ClinicalTrial ID NCT02170246 Disease Liver fibrosis
Phase Phase 1 Status Unknown
First Received June 23, 2014 Last Verified January 26, 2015
Sponsor Yale University

Trial Record 3

ClinicalTrial ID NCT02750059 Disease Cystic fibrosis
Phase Phase 2 Status Active, not recruiting
First Received April 25, 2016 Last Verified April 18, 2018
Sponsor South East Asia Research Collaboration with Hawaii

Related Link

PubChem: 65999
ChEMBL: CHEMBL1017