Type-1 angiotensin II receptor

Basic Information

Uniprot ID: P30556
Secondary ID: Q13725, Q8TBK4
Symbol: AGTR1
Other Name: AGTR1A,AT1AR,AT1BR,Angiotensin II type-1 receptor,AT1
Class: Single Protein
Type: pro-fibrotic
Molecular Function: G-protein coupled receptor,Receptor,Transducer

Target Classification

Category I Category II Category III
Extracellular G protein-coupled receptor Angiotensin receptor

Related Compound

Target ID Name Interaction
D0029 Telmisartan antagonist
D0030 Olmesartan antagonist
D0044 Losartan blocker
D0150 Valsartan antagonist
D0240 Candesartan antagonist
D0365 Irbesartan antagonist
D0486 Olmesartan medoxomil antagonist
D0512 TCV-116 antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 28656296 Compound ID D0029
CAS 144701-48-4 Name Telmisartan
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ACE2-Ang-MasR axis

Reference Record 2

PubMed ID 28656296 Compound ID D0030
CAS 144689-24-7 Name Olmesartan
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ACE2-Ang-MasR axis

Reference Record 3

PubMed ID 28578904 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model vitro Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting RAS signaling, Wnt/β-catenin signaling

Reference Record 4

PubMed ID 27519769 Compound ID D0029
CAS 144701-48-4 Name Telmisartan
Model vitro,human,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting PPARδ/STAT3 pathway

Reference Record 5

PubMed ID 27275467 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model human Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 27108902 Compound ID D0150
CAS 137862-53-4 Name Valsartan
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting XBP1S

Reference Record 7

PubMed ID 26657532 Compound ID D0029
CAS 144701-48-4 Name Telmisartan
Model vitro Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β 1/Smad signaling

Reference Record 8

PubMed ID 26626074 Compound ID
CAS Name
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting mTOR/p70S6K signaling

Reference Record 9

PubMed ID 25411386 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting β-catenin

Reference Record 10

PubMed ID 24473559 Compound ID
CAS Name
Model human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 11

PubMed ID 24342995 Compound ID D0030
CAS 144689-24-7 Name Olmesartan
Model vitro,human,rabbit Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting CatK

Reference Record 12

PubMed ID 23762250 Compound ID D0150
CAS 137862-53-4 Name Valsartan
Model mice Fibrosis Disease Lacrimal gland fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 23762250 Compound ID D0150
CAS 137862-53-4 Name Valsartan
Model mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 23762250 Compound ID D0150
CAS 137862-53-4 Name Valsartan
Model mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 21844822 Compound ID D0030
CAS 144689-24-7 Name Olmesartan
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 21827824 Compound ID D0030
CAS 144689-24-7 Name Olmesartan
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism Targeting AT-1R/MAPK cascade

Reference Record 17

PubMed ID 21769867 Compound ID D0365
CAS 138402-11-6 Name Irbesartan
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 18

PubMed ID 21720156 Compound ID D0029
CAS 144701-48-4 Name Telmisartan
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting mTOR/S6K1 signaling

Reference Record 19

PubMed ID 21562229 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β and IGF-1/Akt/mTOR signaling

Reference Record 20

PubMed ID 21537828 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II EMT,myofibroblasts differentiation
Process III
Mechanism Targeting Pai-i and α-Sma

Reference Record 21

PubMed ID 21518553 Compound ID
CAS Name
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism Targeting Smad3 and Smad7

Reference Record 22

PubMed ID 21464581 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model vitro,rat Fibrosis Disease Pancreatic fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting p38 signaling pathway

Reference Record 23

PubMed ID 20719975 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 24

PubMed ID 20400910 Compound ID
CAS Name
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 25

PubMed ID 19782079 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 26

PubMed ID 18787107 Compound ID D0150
CAS 137862-53-4 Name Valsartan
Model vitro,mice Fibrosis Disease Pancreatic fibrosis
Process I
Process II cells proliferation,cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 27

PubMed ID 18423812 Compound ID D0029
CAS 144701-48-4 Name Telmisartan
Model human Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 28

PubMed ID 18313605 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model rabbit Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 29

PubMed ID 18055516 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 30

PubMed ID 17227571 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model human Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 31

PubMed ID 16971004 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB

Reference Record 32

PubMed ID 16971004 Compound ID D0365
CAS 138402-11-6 Name Irbesartan
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB

Reference Record 33

PubMed ID 15276022 Compound ID D0030
CAS 144689-24-7 Name Olmesartan
Model mice Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 34

PubMed ID 15097243 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 35

PubMed ID 12569276 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 36

PubMed ID 12270869 Compound ID D0486
CAS 144689-63-4 Name Olmesartan medoxomil
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 37

PubMed ID 11961044 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model rat Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 38

PubMed ID 11961044 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 39

PubMed ID 16893502 Compound ID D0150
CAS 137862-53-4 Name Valsartan
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 40

PubMed ID 16141465 Compound ID D0029
CAS 144701-48-4 Name Telmisartan
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 41

PubMed ID 15149348 Compound ID D0365
CAS 138402-11-6 Name Irbesartan
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 42

PubMed ID 15502641 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model rat Fibrosis Disease Pancreatic fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 43

PubMed ID 12411096 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 44

PubMed ID 11961044 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Rho/ Rho-kinase and ERK/p70S6 kinase pathway

Reference Record 45

PubMed ID 11961044 Compound ID D0240
CAS 139481-59-7 Name Candesartan
Model rat Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Rho/ Rho-kinase and ERK/p70S6 kinase pathway

Reference Record 46

PubMed ID 11847192 Compound ID D0512
CAS 145040-37-5 Name TCV-116
Model rat Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 47

PubMed ID 11087260 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 48

PubMed ID 10760085 Compound ID D0044
CAS 114798-26-4 Name Losartan
Model rat Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 49

PubMed ID 29872491 Compound ID D0030
CAS 144689-24-7 Name Olmesartan
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting periostin