Olmesartan

Basic Information

CAS ID:	144689-24-7
Molecular Formula:	C24H26N6O3
Molecular Weight:	446.5 g/mol
Monoisotopic Mass:	446.2066 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	OLMESARTAN \| RNH-6270
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)	See All
InChI Key:	VTRAEEWXHOVJFV-UHFFFAOYSA-N
Smiles:	CCCc1nc(c(C(=O)O)n1Cc2ccc(cc2)c3ccccc3c4nnn[nH]4)C(C)(C)O	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T0118	Type-1 angiotensin II receptor	antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID	28656296	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting ACE2-Ang-MasR axis

Reference Record 2

PubMed ID	24603116	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	24342995	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	vitro,human,rabbit	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting CatK

Reference Record 4

PubMed ID	23477656	Target ID
Uniprot ID		Name
Model	vitro,mice	Fibrosis Disease	Pancreatic fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	23188126	Target ID
Uniprot ID		Name
Model	mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID	22497476	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting ACE-2 and ANG 1-7 mas receptor

Reference Record 7

PubMed ID	21844822	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID	21827824	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	cells apoptosis
Process III	prevenet collagen deposition
Mechanism	Targeting AT-1R/MAPK cascade

Reference Record 9

PubMed ID	15276022	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	mice	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID	17170375	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Vascular fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID	29872491	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting periostin

Related Link

PubChem:	158781
ChEMBL:	CHEMBL1516