PF562271

Basic Information

CAS ID: 717907-75-0
Molecular Formula: C21H20F3N7O3S
Molecular Weight: 507.5 g/mol
Monoisotopic Mass: 507.13 g/mol
Class: Small Molecule
Natural Product: No
Other Names: PF-562271 | PF-00562271
Analysis: Drug repositioning mechanism analysis

N N NH N NH NH O N F F F S O O

Compound Structure and Identifier

InChI: InChI=1S/C21H20F3N7O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30) See All
InChI Key: MZDKLVOWGIOKTN-UHFFFAOYSA-N
Smiles: CN(c1ncccc1CNc2nc(Nc3ccc4NC(=O)Cc4c3)ncc2C(F)(F)F)S(=O)(=O)C See All
Molfile: Download

Related Target

Target ID Name Interaction
T0409 Focal adhesion kinase 1 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28642549 Target ID T0409
Uniprot ID Focal adhesion kinase 1 Name Focal adhesion kinase 1
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,myofibroblasts differentiation, HSCs migration
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 22962065 Target ID T0409
Uniprot ID Focal adhesion kinase 1 Name Focal adhesion kinase 1
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 22492165 Target ID T0409
Uniprot ID Focal adhesion kinase 1 Name Focal adhesion kinase 1
Model vitro,human,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 11713159
ChEMBL: CHEMBL1084546