Focal adhesion kinase 1

Basic Information

Uniprot ID: Q05397
Secondary ID: B4E2N6
Symbol: PTK2
Other Name: FAK,FADK 1,Focal adhesion kinase-related nonkinase,FRNK,Protein phosphatase 1 regulatory subunit 71,PPP1R71,Protein-tyrosine kinase 2,p125FAK,pp125FAK
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Developmental protein,Kinase,Transferase,Tyrosine-protein kinase

Target Classification

Category I Category II Category III
Intracellular Enzyme Kinase

Related Compound

Target ID Name Interaction
D0032 PF562271 inhibitor
D0302 TAE226 inhibitor
D0537 Glabridin inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28642549 Compound ID D0032
CAS 717907-75-0 Name PF562271
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,myofibroblasts differentiation, HSCs migration
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 23642017 Compound ID D0302
CAS 761437-28-9 Name TAE226
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation,fibroblasts differentiation
Process III
Mechanism

Reference Record 3

PubMed ID 22962065 Compound ID D0032
CAS 717907-75-0 Name PF562271
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 22492165 Compound ID D0032
CAS 717907-75-0 Name PF562271
Model vitro,human,mice Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 20731027 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting MMP-13 and TIMP-1

Reference Record 6

PubMed ID 27181267 Compound ID D0537
CAS 59870-68-7 Name Glabridin
Model vitro Fibrosis Disease Scar
Process I
Process II
Process III prevenet collagen deposition
Mechanism