Losartan

Basic Information

CAS ID: 114798-26-4
Molecular Formula: C22H23ClN6O
Molecular Weight: 422.9 g/mol
Monoisotopic Mass: 422.1622 g/mol
Class: Small Molecule
Natural Product: No
Other Names: Hyzaar | DUP 753 | LOSARTAN POTASSIUM | LOSAPREX | LOSARTAN | COZAAR
Analysis: Drug repositioning mechanism analysis

N Cl HO N N N N NH

Compound Structure and Identifier

InChI: InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) See All
InChI Key: PSIFNNKUMBGKDQ-UHFFFAOYSA-N
Smiles: CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)c3ccccc3c4nnn[nH]4 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0118 Type-1 angiotensin II receptor blocker

Related Fibrosis Property

Reference Record 1

PubMed ID 28578904 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting RAS signaling, Wnt/β-catenin signaling

Reference Record 2

PubMed ID 28455747 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ERK1/2 pathway

Reference Record 3

PubMed ID 27275467 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model human Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 24632204 Target ID
Uniprot ID Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II EndMT
Process III
Mechanism

Reference Record 5

PubMed ID 23673415 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ERK/Smad signaling

Reference Record 6

PubMed ID 23528876 Target ID
Uniprot ID Name
Model rabbit Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 21562229 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGF-β and IGF-1/Akt/mTOR signaling

Reference Record 8

PubMed ID 21537828 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II EMT,myofibroblasts differentiation
Process III
Mechanism Targeting Pai-i and α-Sma

Reference Record 9

PubMed ID 21464581 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro,rat Fibrosis Disease Pancreatic fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting p38 signaling pathway

Reference Record 10

PubMed ID 19782079 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro,mice Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 11

PubMed ID 17227571 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model human Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 12

PubMed ID 16971004 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB

Reference Record 13

PubMed ID 20881240 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 15502641 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model rat Fibrosis Disease Pancreatic fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 12411096 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 11087260 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 10760085 Target ID T0118
Uniprot ID Type-1 angiotensin II receptor Name Type-1 angiotensin II receptor
Model rat Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID NCT03206788 Disease Cystic fibrosis
Phase Phase 2 Status Recruiting
First Received July 2, 2017 Last Verified September 11, 2018
Sponsor University of Miami

Trial Record 2

ClinicalTrial ID NCT00981747 Disease Idiopathic pulmonary fibrosis
Phase Phase 2,Phase 3 Status Terminated
First Received September 22, 2009 Last Verified November 12, 2018
Sponsor Alicia Gerke

Trial Record 3

ClinicalTrial ID NCT02049307 Disease Fibrosis
Phase Phase 2 Status Active, not recruiting
First Received January 30, 2014 Last Verified March 22, 2018
Sponsor Minneapolis Medical Research Foundation

Trial Record 4

ClinicalTrial ID NCT00880386 Disease Pulmonary fibrosis
Phase Not Applicable Status Withdrawn
First Received April 13, 2009 Last Verified May 2, 2017
Sponsor University of South Florida

Trial Record 5

ClinicalTrial ID NCT00467831 Disease Pulmonary fibrosis
Phase Phase 1,Phase 2 Status Terminated
First Received May 1, 2007 Last Verified August 2, 2013
Sponsor National Human Genome Research Institute (NHGRI)

Trial Record 6

ClinicalTrial ID NCT00298714 Disease Liver fibrosis
Phase Phase 4 Status Completed
First Received March 3, 2006 Last Verified November 22, 2007
Sponsor Hospital Clinic of Barcelona

Trial Record 7

ClinicalTrial ID NCT00879879 Disease Idiopathic pulmonary fibrosis
Phase Not Applicable Status Completed
First Received April 13, 2009 Last Verified October 14, 2013
Sponsor University of South Florida

Trial Record 8

ClinicalTrial ID NCT01852942 Disease Liver fibrosis
Phase Phase 2 Status Active, not recruiting
First Received May 14, 2013 Last Verified October 11, 2018
Sponsor University of Minnesota - Clinical and Translational Science Institute

Trial Record 9

ClinicalTrial ID NCT01529749 Disease Liver fibrosis
Phase Phase 4 Status Completed
First Received February 9, 2012 Last Verified February 19, 2016
Sponsor Felipe Garcia

Trial Record 10

ClinicalTrial ID NCT00239096 Disease Liver fibrosis
Phase Phase 4 Status Unknown
First Received October 14, 2005 Last Verified October 14, 2005
Sponsor Odense University Hospital

Trial Record 11

ClinicalTrial ID NCT01051219 Disease Liver fibrosis
Phase Phase 3 Status Completed
First Received January 18, 2010 Last Verified October 7, 2015
Sponsor Newcastle-upon-Tyne Hospitals NHS Trust

Related Link

PubChem: 3961
ChEMBL: CHEMBL191