ICG-001

Basic Information

CAS ID:	780757-88-2
Molecular Formula:	C33H32N4O4
Molecular Weight:	548.6 g/mol
Monoisotopic Mass:	548.2424 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C33H32N4O4/c38-27-15-13-23(14-16-27)19-29-32(40)35(21-26-11-6-10-25-9-4-5-12-28(25)26)22-30-36(18-17-31(39)37(29)30)33(41)34-20-24-7-2-1-3-8-24/h1-16,29-30,38H,17-22H2,(H,34,41)/t29-,30+/m0/s1	See All
InChI Key:	HQWTUOLCGKIECB-XZWHSSHBSA-N
Smiles:	Oc1ccc(C[C@@H]2N3[C@H](CN(Cc4cccc5ccccc45)C2=O)N(CCC3=O)C(=O)NCc6ccccc6)cc1	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T0667	CREB-binding protein	antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID	28578904	Target ID	T0667
Uniprot ID	CREB-binding protein	Name	CREB-binding protein
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting RAS signaling, Wnt/β-catenin signaling

Reference Record 2

PubMed ID	27307790	Target ID	T0667
Uniprot ID	CREB-binding protein	Name	CREB-binding protein
Model	vitro,mice	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID	25012166	Target ID	T0667
Uniprot ID	CREB-binding protein	Name	CREB-binding protein
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Wnt/β-catenin signaling

Reference Record 4

PubMed ID	21816937	Target ID
Uniprot ID		Name
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting β-catenin/CBP signaling

Related Link

PubChem:	11238147
ChEMBL:	CHEMBL2312139