Paricalcitol

Basic Information

CAS ID: 131918-61-1
Molecular Formula: C27H44O3
Molecular Weight: 416.7 g/mol
Monoisotopic Mass: 416.329 g/mol
Class: Small Molecule
Natural Product: No
Other Names: ZEMPLAR | COMPOUND 49510 | PARICALCITOL
Analysis: Drug repositioning mechanism analysis

OH OH HO

Compound Structure and Identifier

InChI: InChI=1S/C27H44O3/c1-18(8-9-19(2)26(3,4)30)24-12-13-25-21(7-6-14-27(24,25)5)11-10-20-15-22(28)17-23(29)16-20/h8-11,18-19,22-25,28-30H,6-7,12-17H2,1-5H3/b9-8+,21-11+/t18-,19+,22-,23-,24-,25+,27-/m1/s1 See All
InChI Key: BPKAHTKRCLCHEA-UBFJEZKGSA-N
Smiles: C[C@H](\C=C\[C@H](C)C(C)(C)O)[C@H]1CC[C@H]2\C(=C\C=C3C[C@@H](O)C[C@H](O)C3)\CCC[C@]12C See All
Molfile: Download

Related Target

Target ID Name Interaction
T0534 Vitamin D3 receptor activator

Related Fibrosis Property

Reference Record 1

PubMed ID 28460073 Target ID T0534
Uniprot ID Vitamin D3 receptor Name Vitamin D3 receptor
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting miR-29b and miR-30c

Reference Record 2

PubMed ID 24448349 Target ID T0534
Uniprot ID Vitamin D3 receptor Name Vitamin D3 receptor
Model vitro,human,mice Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts activation,fibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 21565836 Target ID
Uniprot ID Name
Model vitro,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Trial Record 1

ClinicalTrial ID NCT00587158 Disease Renal fibrosis
Phase Not Applicable Status Completed
First Received January 7, 2008 Last Verified May 13, 2013
Sponsor Mayo Clinic

Related Link

PubChem: 5281104
ChEMBL: CHEMBL1200622