Vitamin D3 receptor

Basic Information

Uniprot ID:	P11473
Secondary ID:	B2R5Q1, G3V1V9, Q5PSV3
Symbol:	VDR
Other Name:	NR1I1,VDR,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1
Class:	Single Protein
Type:	anti-fibrotic
Molecular Function:	DNA-binding,Receptor

Target Classification

Category I	Category II	Category III
Intracellular	Nuclear receptor	NR1 family

Related Compound

Target ID	Name	Interaction
D0057	Calcitriol	activator
D0058	Paricalcitol	activator
D0305	Calcipotriol	agonist
D0323	Doxercalciferol	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28460073	Compound ID	D0057
CAS	32222-06-3	Name	Calcitriol
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting miR-29b and miR-30c

Reference Record 2

PubMed ID	28460073	Compound ID	D0058
CAS	131918-61-1	Name	Paricalcitol
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting miR-29b and miR-30c

Reference Record 3

PubMed ID	24448349	Compound ID	D0058
CAS	131918-61-1	Name	Paricalcitol
Model	vitro,human,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II	fibroblasts activation,fibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	23123403	Compound ID	D0323
CAS	54573-75-0	Name	Doxercalciferol
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism