TRAM-34

Basic Information

CAS ID: 289905-88-0
Molecular Formula: C22H17ClN2
Molecular Weight: 344.9 g/mol
Monoisotopic Mass: 344.108 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

Cl N N

Compound Structure and Identifier

InChI: InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H See All
InChI Key: KBFUQFVFYYBHBT-UHFFFAOYSA-N
Smiles: Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0171 Intermediate conductance calcium-activated potassium channel protein 4 blocker

Related Fibrosis Property

Reference Record 1

PubMed ID 28455747 Target ID T0171
Uniprot ID Intermediate conductance calcium-activated potassium channel protein 4 Name Intermediate conductance calcium-activated potassium channel protein 4
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism Targeting ERK1/2 pathway

Reference Record 2

PubMed ID 27592222 Target ID T0171
Uniprot ID Intermediate conductance calcium-activated potassium channel protein 4 Name Intermediate conductance calcium-activated potassium channel protein 4
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ACE2-Ang-(1-7)-Mas and KCa3.1 channel

Reference Record 3

PubMed ID 26160442 Target ID T0171
Uniprot ID Intermediate conductance calcium-activated potassium channel protein 4 Name Intermediate conductance calcium-activated potassium channel protein 4
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation,fibroblasts differetiation
Process III prevenet collagen deposition
Mechanism Targeting AKT and ERK1/2 signaling

Reference Record 4

PubMed ID 24312257 Target ID T0171
Uniprot ID Intermediate conductance calcium-activated potassium channel protein 4 Name Intermediate conductance calcium-activated potassium channel protein 4
Model human,mice,rat Fibrosis Disease Aortic fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 24166472 Target ID T0171
Uniprot ID Intermediate conductance calcium-activated potassium channel protein 4 Name Intermediate conductance calcium-activated potassium channel protein 4
Model vitro,human,mice Fibrosis Disease Renal fibrosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 19706538 Target ID T0171
Uniprot ID Intermediate conductance calcium-activated potassium channel protein 4 Name Intermediate conductance calcium-activated potassium channel protein 4
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 656734
ChEMBL: CHEMBL498270