Intermediate conductance calcium-activated potassium channel protein 4

Basic Information

Uniprot ID: O15554
Secondary ID: Q53XR4
Symbol: KCNN4
Other Name: IK1,SK4,SKCa 4,SKCa4,IKCa1,IK1,KCa3.1,KCa4,Putative Gardos channel
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Calmodulin-binding,Ion channel

Target Classification

Category I Category II Category III
Extracellular Ion channel protein Potassium channel

Related Compound

Target ID Name Interaction
D0059 TRAM-34 blocker
D0360 Clotrimazole inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28455747 Compound ID D0059
CAS 289905-88-0 Name TRAM-34
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism Targeting ERK1/2 pathway

Reference Record 2

PubMed ID 27592222 Compound ID D0059
CAS 289905-88-0 Name TRAM-34
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ACE2-Ang-(1-7)-Mas and KCa3.1 channel

Reference Record 3

PubMed ID 26160442 Compound ID D0059
CAS 289905-88-0 Name TRAM-34
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation,fibroblasts differetiation
Process III prevenet collagen deposition
Mechanism Targeting AKT and ERK1/2 signaling

Reference Record 4

PubMed ID 24392001 Compound ID
CAS Name
Model vitro Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II myofibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 24312257 Compound ID D0059
CAS 289905-88-0 Name TRAM-34
Model human,mice,rat Fibrosis Disease Aortic fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 24166472 Compound ID D0059
CAS 289905-88-0 Name TRAM-34
Model vitro,human,mice Fibrosis Disease Renal fibrosis
Process I
Process II fibroblasts activation
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 23656889 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism TGF-β1/Smad signaling

Reference Record 8

PubMed ID 21909392 Compound ID D0360
CAS 23593-75-1 Name Clotrimazole
Model human Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 19706538 Compound ID D0059
CAS 289905-88-0 Name TRAM-34
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism