PP2

Basic Information

CAS ID: 172889-27-9
Molecular Formula: C15H16ClN5
Molecular Weight: 301.8 g/mol
Monoisotopic Mass: 301.1094 g/mol
Class: Small Molecule
Natural Product: No
Other Names: AG-1879
Analysis: Drug repositioning mechanism analysis

N N Cl H2N N N

Compound Structure and Identifier

InChI: InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19) See All
InChI Key: PBBRWFOVCUAONR-UHFFFAOYSA-N
Smiles: CC(C)(C)n1nc(c2ccc(Cl)cc2)c3c(N)ncnc13 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0359 Proto-oncogene tyrosine-protein kinase Src inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28397850 Target ID T0359
Uniprot ID Proto-oncogene tyrosine-protein kinase Src Name Proto-oncogene tyrosine-protein kinase Src
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts migration
Process III prevenet collagen deposition
Mechanism Targeting Src signaling

Reference Record 2

PubMed ID 27629435 Target ID T0359
Uniprot ID Proto-oncogene tyrosine-protein kinase Src Name Proto-oncogene tyrosine-protein kinase Src
Model vitro,mice Fibrosis Disease Cystic fibrosis
Process I regulate cytokines and growth factors,attenue inflammation
Process II macrophage accumulation
Process III
Mechanism Targeting SFK activity

Reference Record 3

PubMed ID 17135298 Target ID T0359
Uniprot ID Proto-oncogene tyrosine-protein kinase Src Name Proto-oncogene tyrosine-protein kinase Src
Model vitro Fibrosis Disease Fibrosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting ERK1/2

Related Link

PubChem: 4878
ChEMBL: CHEMBL406845