Proto-oncogene tyrosine-protein kinase Src

Basic Information

Uniprot ID:	P12931
Secondary ID:	E1P5V4
Symbol:	SRC
Other Name:	SRC1,Proto-oncogene c-Src,pp60c-src,p60-Src
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Kinase,Transferase,Tyrosine-protein kinase

Target Classification

Category I	Category II	Category III
Intracellular	Enzyme	Kinase

Related Compound

Target ID	Name	Interaction
D0015	Dasatinib	inhibitor
D0069	PP2	inhibitor
D0182	PP1	inhibitor
D0458	SU-6656	inhibitor
D0525	KX2-391	inhibitor
D0537	Glabridin	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	28775044	Compound ID	D0015
CAS	302962-49-8	Name	Dasatinib
Model	vitro	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II	cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	28397850	Compound ID	D0069
CAS	172889-27-9	Name	PP2
Model	vitro,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II	fibroblasts migration
Process III	prevenet collagen deposition
Mechanism	Targeting Src signaling

Reference Record 3

PubMed ID	27629435	Compound ID	D0069
CAS	172889-27-9	Name	PP2
Model	vitro,mice	Fibrosis Disease	Cystic fibrosis
Process I	regulate cytokines and growth factors,attenue inflammation
Process II	macrophage accumulation
Process III
Mechanism	Targeting SFK activity

Reference Record 4

PubMed ID	26444028	Compound ID	D0182
CAS	172889-26-8	Name	PP1
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	fibroblasts activation,fibroblasts proliferation
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	17135298	Compound ID	D0069
CAS	172889-27-9	Name	PP2
Model	vitro	Fibrosis Disease	Fibrosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting ERK1/2

Reference Record 6

PubMed ID	17135298	Compound ID	D0458
CAS	330161-87-0	Name	SU-6656
Model	vitro	Fibrosis Disease	Fibrosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting ERK1/2

Reference Record 7

PubMed ID	29137389	Compound ID	D0525
CAS	897016-82-9	Name	KX2-391
Model	vitro	Fibrosis Disease	Peritoneal fibrosis
Process I	attenue inflammation
Process II	EMT,fibroblasts activation
Process III	prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID	27181267	Compound ID	D0537
CAS	59870-68-7	Name	Glabridin
Model	vitro	Fibrosis Disease	Scar
Process I
Process II
Process III	prevenet collagen deposition
Mechanism