AG1478

Basic Information

CAS ID:	153436-53-4
Molecular Formula:	C16H14ClN3O2
Molecular Weight:	315.8 g/mol
Monoisotopic Mass:	315.0775 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	AG-1478
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)	See All
InChI Key:	GFNNBHLJANVSQV-UHFFFAOYSA-N
Smiles:	COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T0022	Epidermal growth factor receptor	antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID	28374780	Target ID	T0022
Uniprot ID	Epidermal growth factor receptor	Name	Epidermal growth factor receptor
Model	vitro,mice	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	27317889	Target ID	T0022
Uniprot ID	Epidermal growth factor receptor	Name	Epidermal growth factor receptor
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	cell activation
Process III	prevenet collagen deposition
Mechanism	Targeting Aldosterone-ROS-EGFR-ERK1/2 signaling

Reference Record 3

PubMed ID	27087279	Target ID	T0022
Uniprot ID	Epidermal growth factor receptor	Name	Epidermal growth factor receptor
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting TLR4 and c-Src

Reference Record 4

PubMed ID	25758431	Target ID	T0022
Uniprot ID	Epidermal growth factor receptor	Name	Epidermal growth factor receptor
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	24303948	Target ID	T0022
Uniprot ID	Epidermal growth factor receptor	Name	Epidermal growth factor receptor
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,cells apoptosis
Process III
Mechanism

Reference Record 6

PubMed ID	23086930	Target ID	T0022
Uniprot ID	Epidermal growth factor receptor	Name	Epidermal growth factor receptor
Model	vitro,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II	fibroblasts proliferation,myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting EGFR signaling

Reference Record 7

PubMed ID	20097367	Target ID	T0022
Uniprot ID	Epidermal growth factor receptor	Name	Epidermal growth factor receptor
Model	rat	Fibrosis Disease	Biliary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Related Link

PubChem:	2051
ChEMBL:	CHEMBL7917