Epidermal growth factor receptor

Basic Information

Uniprot ID:	P00533
Secondary ID:	O00688
Symbol:	EGFR
Other Name:	ERBB,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	Developmental protein,Host cell receptor for virus entry,Kinase,Receptor,Transferase,Tyrosine-protein kinase

Target Classification

Category I	Category II	Category III
Extracellular	Growth factor and receptor	EGFR family

Related Compound

Target ID	Name	Interaction
D0071	AG1478	antagonist
D0072	EGFR-IN-542	inhibitor
D0134	Erlotinib	antagonist
D0220	Compound 451	inhibitor
D0324	Gefitinib	antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID	28374780	Compound ID	D0071
CAS	153436-53-4	Name	AG1478
Model	vitro,mice	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	28374780	Compound ID	D0072
CAS	1639040-81-5	Name	EGFR-IN-542
Model	vitro,mice	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	27317889	Compound ID	D0134
CAS	183321-74-6	Name	Erlotinib
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	cell activation
Process III	prevenet collagen deposition
Mechanism	Targeting Aldosterone-ROS-EGFR-ERK1/2 signaling

Reference Record 4

PubMed ID	27317889	Compound ID	D0071
CAS	153436-53-4	Name	AG1478
Model	vitro,rat	Fibrosis Disease	Renal fibrosis
Process I
Process II	cell activation
Process III	prevenet collagen deposition
Mechanism	Targeting Aldosterone-ROS-EGFR-ERK1/2 signaling

Reference Record 5

PubMed ID	27087279	Compound ID	D0071
CAS	153436-53-4	Name	AG1478
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting TLR4 and c-Src

Reference Record 6

PubMed ID	27087279	Compound ID	D0072
CAS	1639040-81-5	Name	EGFR-IN-542
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting TLR4 and c-Src

Reference Record 7

PubMed ID	25758431	Compound ID	D0220
CAS	220576-72-7	Name	Compound 451
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID	25758431	Compound ID	D0071
CAS	153436-53-4	Name	AG1478
Model	vitro,mice	Fibrosis Disease	Cardiac fibrosis
Process I
Process II	cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID	24303948	Compound ID	D0071
CAS	153436-53-4	Name	AG1478
Model	vitro,rat	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,cells apoptosis
Process III
Mechanism

Reference Record 10

PubMed ID	23086930	Compound ID	D0071
CAS	153436-53-4	Name	AG1478
Model	vitro,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II	fibroblasts proliferation,myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting EGFR signaling

Reference Record 11

PubMed ID	23086930	Compound ID	D0324
CAS	184475-35-2	Name	Gefitinib
Model	vitro,mice	Fibrosis Disease	Idiopathic pulmonary fibrosis
Process I
Process II	fibroblasts proliferation,myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting EGFR signaling

Reference Record 12

PubMed ID	22095949	Compound ID	D0134
CAS	183321-74-6	Name	Erlotinib
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID	20097367	Compound ID	D0071
CAS	153436-53-4	Name	AG1478
Model	rat	Fibrosis Disease	Biliary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism