EGFR-IN-542

Basic Information

CAS ID: 1639040-81-5
Molecular Formula: C23H18FN5
Molecular Weight: 383.43 g/mol
Monoisotopic Mass: 383.155 g/mol
Class: Small Molecule
Natural Product: No
Other Names: 4,6-Quinazolinediamine, N4-[1-[(3-fluorophenyl)methyl]-1H-indol-5-yl]-
Analysis: Drug repositioning mechanism analysis

NH2 NH N F N N

Compound Structure and Identifier

InChI: InChI=1S/C23H18FN5/c24-17-3-1-2-15(10-17)13-29-9-8-16-11-19(5-7-22(16)29)28-23-20-12-18(25)4-6-21(20)26-14-27-23/h1-12,14H,13,25H2,(H,26,27,28) See All
InChI Key:
Smiles: NC1=CC2=C(NC3=CC4=C(N(CC5=CC=CC(F)=C5)C=C4)C=C3)N=CN=C2C=C1 See All
Molfile:

Related Target

Target ID Name Interaction
T0022 Epidermal growth factor receptor inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 27087279 Target ID T0022
Uniprot ID Epidermal growth factor receptor Name Epidermal growth factor receptor
Model vitro,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism Targeting TLR4 and c-Src

Reference Record 2

PubMed ID 28374780 Target ID T0022
Uniprot ID Epidermal growth factor receptor Name Epidermal growth factor receptor
Model vitro,mice Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem:
ChEMBL: