A438079

Basic Information

CAS ID: 899507-36-9
Molecular Formula: C13H9Cl2N5
Molecular Weight: 306.2 g/mol
Monoisotopic Mass: 305.0235 g/mol
Class: Small Molecule
Natural Product: No
Other Names: A-438079
Analysis: Drug repositioning mechanism analysis

Cl Cl N N N N N

Compound Structure and Identifier

InChI: InChI=1S/C13H9Cl2N5/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9/h1-7H,8H2 See All
InChI Key: MMPAULQSJLVKHP-UHFFFAOYSA-N
Smiles: Clc1cccc(c1Cl)c2nnnn2Cc3cccnc3 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0127 P2X purinoceptor 7 antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID 28061416 Target ID T0127
Uniprot ID P2X purinoceptor 7 Name P2X purinoceptor 7
Model vitro Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSC activation,HSC proliferation
Process III prevenet collagen deposition
Mechanism Targeting PKC-dependent GSK3β pathway

Reference Record 2

PubMed ID 27940204 Target ID T0127
Uniprot ID P2X purinoceptor 7 Name P2X purinoceptor 7
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 24247209 Target ID T0127
Uniprot ID P2X purinoceptor 7 Name P2X purinoceptor 7
Model rat Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 21918525 Target ID T0127
Uniprot ID P2X purinoceptor 7 Name P2X purinoceptor 7
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 11673921
ChEMBL: CHEMBL377219