P2X purinoceptor 7

Basic Information

Uniprot ID: Q99572
Secondary ID: A8K2Z0
Symbol: P2RX7
Other Name: P2X7,ATP receptor,P2Z receptor,Purinergic receptor
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Ion channel,Ligand-gated ion channel,Receptor

Target Classification

Category I Category II Category III
Extracellular G protein-coupled receptor Purine receptor

Related Compound

Target ID Name Interaction
D0092 A438079 antagonist
D0357 Brilliant blue G antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID 28061416 Compound ID D0092
CAS 899507-36-9 Name A438079
Model vitro Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II HSC activation,HSC proliferation
Process III prevenet collagen deposition
Mechanism Targeting PKC-dependent GSK3β pathway

Reference Record 2

PubMed ID 27940204 Compound ID D0092
CAS 899507-36-9 Name A438079
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 26461208 Compound ID
CAS Name
Model mice Fibrosis Disease Muscle fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 24247209 Compound ID D0092
CAS 899507-36-9 Name A438079
Model rat Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 24157968 Compound ID
CAS Name
Model mice Fibrosis Disease Liver fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 22859404 Compound ID
CAS Name
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID 21918525 Compound ID D0092
CAS 899507-36-9 Name A438079
Model rat Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 21918525 Compound ID D0357
CAS 6104-58-1 Name Brilliant blue G
Model rat Fibrosis Disease Renal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 9

PubMed ID 28955239 Compound ID
CAS Name
Model vitro,human Fibrosis Disease Systemic sclerosis
Process I
Process II fibroblasts migration
Process III prevenet collagen deposition
Mechanism