Troglitazone

Basic Information

CAS ID: 97322-87-7
Molecular Formula: C24H27NO5S
Molecular Weight: 441.6 g/mol
Monoisotopic Mass: 441.161 g/mol
Class: Small Molecule
Natural Product: No
Other Names: TROGLITAZONE | PRELAY | CI-991 | GR-92132X | ROMOZIN | CS-045 | GR92132X | REZULIN
Analysis: Drug repositioning mechanism analysis

O O S O NH O HO

Compound Structure and Identifier

InChI: InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28) See All
InChI Key: GXPHKUHSUJUWKP-UHFFFAOYSA-N
Smiles: Cc1c(C)c2OC(C)(COc3ccc(CC4SC(=O)NC4=O)cc3)CCc2c(C)c1O See All
Molfile: Download

Related Target

Target ID Name Interaction
T0526 Peroxisome proliferator-activated receptor gamma agonist

Related Fibrosis Property

Reference Record 1

PubMed ID 27429849 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model vitro,human Fibrosis Disease Keloid
Process I
Process II
Process III
Mechanism Targeting PPAR-γ-miR-543-Egr1 signaling axis

Reference Record 2

PubMed ID 25704091 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model vitro Fibrosis Disease Scar
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Smad3

Reference Record 3

PubMed ID 19120328 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 18162602 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 17199790 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 15211114 Target ID T0526
Uniprot ID Peroxisome proliferator-activated receptor gamma Name Peroxisome proliferator-activated receptor gamma
Model Fibrosis Disease Pancreatic fibrosis
Process I
Process II
Process III
Mechanism

Related Link

PubChem: 5591
ChEMBL: CHEMBL408