Peroxisome proliferator-activated receptor gamma

Basic Information

Uniprot ID: P37231
Secondary ID: A8K3G6
Symbol: PPARG
Other Name: NR1C3,PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
Class: Single Protein
Type: pro/anti-fibrotic
Molecular Function: Activator,DNA-binding,Receptor

Target Classification

Category I Category II Category III
Intracellular Nuclear receptor NR1 family

Related Compound

Target ID Name Interaction
D0026 Honokiol agonist
D0131 Troglitazone agonist
D0289 15d-PGJ2 agonist
D0303 Pioglitazone agonist
D0354 Rosiglitazone agonist
D0587 Osthol agonist
D0968 Ciglitazone agonist

Fibrosis Related Property

Reference Record 1

PubMed ID 28100650 Compound ID
CAS Name
Model vitro Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III
Mechanism Targeting TGF-β signaling

Reference Record 2

PubMed ID 27429849 Compound ID D0131
CAS 97322-87-7 Name Troglitazone
Model vitro,human Fibrosis Disease Keloid
Process I
Process II
Process III
Mechanism Targeting PPAR-γ-miR-543-Egr1 signaling axis

Reference Record 3

PubMed ID 25704091 Compound ID D0131
CAS 97322-87-7 Name Troglitazone
Model vitro Fibrosis Disease Scar
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Smad3

Reference Record 4

PubMed ID 25586556 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 22050182 Compound ID D0354
CAS 122320-73-4 Name Rosiglitazone
Model vitro Fibrosis Disease Vascular fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting mTOR-p70S6K and -4EBP1 systems

Reference Record 6

PubMed ID 21127991 Compound ID D0303
CAS 111025-46-8 Name Pioglitazone
Model vitro Fibrosis Disease Corneal fibrosis
Process I
Process II cells proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting TGFβ

Reference Record 7

PubMed ID 19120328 Compound ID D0131
CAS 97322-87-7 Name Troglitazone
Model vitro Fibrosis Disease Keloid
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 18974632 Compound ID D0303
CAS 111025-46-8 Name Pioglitazone
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID 18622247 Compound ID D0303
CAS 111025-46-8 Name Pioglitazone
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 10

PubMed ID 18556801 Compound ID D0303
CAS 111025-46-8 Name Pioglitazone
Model vitro,mice Fibrosis Disease Cystic fibrosis
Process I attenue inflammation
Process II
Process III
Mechanism

Reference Record 11

PubMed ID 18313605 Compound ID D0303
CAS 111025-46-8 Name Pioglitazone
Model rabbit Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 12

PubMed ID 18162602 Compound ID D0968
CAS 74772-77-3 Name Ciglitazone
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 13

PubMed ID 18162602 Compound ID D0131
CAS 97322-87-7 Name Troglitazone
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts proliferation,myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 14

PubMed ID 17855643 Compound ID
CAS Name
Model mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 15

PubMed ID 17505534 Compound ID D0354
CAS 122320-73-4 Name Rosiglitazone
Model mice Fibrosis Disease Vascular fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 16

PubMed ID 15734787 Compound ID D0289
CAS 87893-55-8 Name 15d-PGJ2
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 17

PubMed ID 15734787 Compound ID D0968
CAS 74772-77-3 Name Ciglitazone
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 18

PubMed ID 15734787 Compound ID D0354
CAS 122320-73-4 Name Rosiglitazone
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II myofibroblasts differentiation
Process III
Mechanism

Reference Record 19

PubMed ID 15112352 Compound ID
CAS Name
Model rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 20

PubMed ID 28973641 Compound ID D0354
CAS 122320-73-4 Name Rosiglitazone
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II EMT
Process III
Mechanism

Reference Record 21

PubMed ID 21854795 Compound ID D0587
CAS 484-12-8 Name Osthol
Model mice Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting NF-κB

Reference Record 22

PubMed ID 20351560 Compound ID D0354
CAS 122320-73-4 Name Rosiglitazone
Model rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 23

PubMed ID 19474275 Compound ID D0026
CAS 35354-74-6 Name Honokiol
Model vitro Fibrosis Disease Fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 24

PubMed ID 17199790 Compound ID D0131
CAS 97322-87-7 Name Troglitazone
Model vitro Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 25

PubMed ID 15211114 Compound ID D0131
CAS 97322-87-7 Name Troglitazone
Model Fibrosis Disease Pancreatic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 26

PubMed ID 29114000 Compound ID
CAS Name
Model vitro,human,mice Fibrosis Disease Cardiac fibrosis
Process I attenue inflammation
Process II myofibroblast differentiation
Process III prevenet collagen deposition
Mechanism Targeting PPARγ