SRT1720

Basic Information

CAS ID: 1001645-58-4
Molecular Formula: C25H23N7OS
Molecular Weight: 469.6 g/mol
Monoisotopic Mass: 469.1685 g/mol
Class: Small Molecule
Natural Product: No
Other Names: SRT-1720
Analysis: Drug repositioning mechanism analysis

O NH N N NH S N N N

Compound Structure and Identifier

InChI: InChI=1S/C25H23N7OS/c33-24(22-13-27-20-7-3-4-8-21(20)28-22)29-19-6-2-1-5-18(19)23-15-32-17(16-34-25(32)30-23)14-31-11-9-26-10-12-31/h1-8,13,15-16,26H,9-12,14H2,(H,29,33) See All
InChI Key: IASPBORHOMBZMY-UHFFFAOYSA-N
Smiles: O=C(Nc1ccccc1c2cn3c(CN4CCNCC4)csc3n2)c5cnc6ccccc6n5 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0671 NAD-dependent protein deacetylase sirtuin-1 activator

Related Fibrosis Property

Reference Record 1

PubMed ID 27387128 Target ID T0671
Uniprot ID NAD-dependent protein deacetylase sirtuin-1 Name NAD-dependent protein deacetylase sirtuin-1
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting miR-34a/SIRT1/p53

Reference Record 2

PubMed ID 27255945 Target ID T0671
Uniprot ID NAD-dependent protein deacetylase sirtuin-1 Name NAD-dependent protein deacetylase sirtuin-1
Model vitro Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting ER stress

Reference Record 3

PubMed ID 20335659 Target ID T0671
Uniprot ID NAD-dependent protein deacetylase sirtuin-1 Name NAD-dependent protein deacetylase sirtuin-1
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II cells apoptosis
Process III prevenet collagen deposition
Mechanism Targeting COX2

Related Link

PubChem: 24180125
ChEMBL: CHEMBL257991