Erlotinib

Basic Information

CAS ID: 183321-74-6
Molecular Formula: C22H23N3O4
Molecular Weight: 393.4 g/mol
Monoisotopic Mass: 393.1689 g/mol
Class: Small Molecule
Natural Product: No
Other Names: CP-358774-01 | RG-1415 | R-1415 | ERLOTINIB HYDROCHLORIDE | CP-358,774-01 | OSI-774 | TARCEVA | ERLOTINIB | Ro-508231 | CP-358774
Analysis: Drug repositioning mechanism analysis

O O N N NH O O

Compound Structure and Identifier

InChI: InChI=1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25) See All
InChI Key: AAKJLRGGTJKAMG-UHFFFAOYSA-N
Smiles: COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC See All
Molfile: Download

Related Target

Target ID Name Interaction
T0022 Epidermal growth factor receptor antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID 22095949 Target ID T0022
Uniprot ID Epidermal growth factor receptor Name Epidermal growth factor receptor
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 27317889 Target ID T0022
Uniprot ID Epidermal growth factor receptor Name Epidermal growth factor receptor
Model vitro,rat Fibrosis Disease Renal fibrosis
Process I
Process II cell activation
Process III prevenet collagen deposition
Mechanism Targeting Aldosterone-ROS-EGFR-ERK1/2 signaling

Related Link

PubChem: 176870
ChEMBL: CHEMBL553