AG1296

Basic Information

CAS ID: 146535-11-7
Molecular Formula: C16H14N2O2
Molecular Weight: 266.3 g/mol
Monoisotopic Mass: 266.1055 g/mol
Class: Small Molecule
Natural Product: No
Other Names: AG-1296
Analysis: Drug repositioning mechanism analysis

O N N O

Compound Structure and Identifier

InChI: InChI=1S/C16H14N2O2/c1-19-15-8-12-13(9-16(15)20-2)18-14(10-17-12)11-6-4-3-5-7-11/h3-10H,1-2H3 See All
InChI Key: QNOXYUNHIGOWNY-UHFFFAOYSA-N
Smiles: COc1cc2ncc(nc2cc1OC)c3ccccc3 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0028 Platelet-derived growth factor receptor beta inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 28158495 Target ID T0028
Uniprot ID Platelet-derived growth factor receptor beta Name Platelet-derived growth factor receptor beta
Model vitro,mice,dog Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting JAK-STAT signaling

Reference Record 2

PubMed ID 27279371 Target ID T0028
Uniprot ID Platelet-derived growth factor receptor beta Name Platelet-derived growth factor receptor beta
Model vitro Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II myofibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Related Link

PubChem: 2049
ChEMBL: CHEMBL71191