Platelet-derived growth factor receptor beta

Basic Information

Uniprot ID: P09619
Secondary ID: B5A957, Q8N5L4
Symbol: PDGFRB
Other Name: PDGFR,PDGF-R-beta,PDGFR-beta,Beta platelet-derived growth factor receptor,Beta-type platelet-derived growth factor receptor,CD140 antigen-like family member B,Platelet-derived growth factor receptor 1,PDGFR-1,
Class: Single Protein
Type: pro-fibrotic
Molecular Function: Developmental protein,Kinase,Receptor,Transferase,Tyrosine-protein kinase

Target Classification

Category I Category II Category III
Extracellular Growth factor and receptor PDGF family

Related Compound

Target ID Name Interaction
D0102 Imatinib antagonist
D0137 AG1296 inhibitor
D0468 SU9518 inhibitor
D0555 AG1295 inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 27279371 Compound ID D0137
CAS 146535-11-7 Name AG1296
Model vitro Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II myofibroblasts proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 26752520 Compound ID D0555
CAS 71897-07-9 Name AG1295
Model vitro,human,rat Fibrosis Disease Cardiac fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 3

PubMed ID 25376624 Compound ID
CAS Name
Model human Fibrosis Disease Peritoneal fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 4

PubMed ID 21716259 Compound ID D0102
CAS 152459-95-5 Name Imatinib
Model mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 18509379 Compound ID
CAS Name
Model vitro,rat Fibrosis Disease Liver fibrosis
Process I
Process II HSCs activation,HSCs proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 16556328 Compound ID D0468
CAS 251356-32-8 Name SU9518
Model vitro Fibrosis Disease Pulmonary fibrosis
Process I
Process II fibroblasts activation,cells proliferation,cells apoptosis
Process III
Mechanism

Reference Record 7

PubMed ID 15978205 Compound ID
CAS Name
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II HSCs proliferation,HSCs apoptosis
Process III prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID 29170419 Compound ID D0102
CAS 152459-95-5 Name Imatinib
Model vitro,human Fibrosis Disease Fibrosis
Process I
Process II cells proliferation
Process III
Mechanism

Reference Record 9

PubMed ID 28424212 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting Akt/mTORC1

Reference Record 10

PubMed ID 28158495 Compound ID D0137
CAS 146535-11-7 Name AG1296
Model vitro,mice,dog Fibrosis Disease Cardiac fibrosis
Process I
Process II fibroblasts proliferation
Process III prevenet collagen deposition
Mechanism Targeting JAK-STAT signaling