Valsartan

Basic Information

CAS ID:	137862-53-4
Molecular Formula:	C24H29N5O3
Molecular Weight:	435.5 g/mol
Monoisotopic Mass:	435.227 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	CGP 48933 \| DIOVAN \| VALSARTAN \| Exforge
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1	See All
InChI Key:	ACWBQPMHZXGDFX-QFIPXVFZSA-N
Smiles:	CCCCC(=O)N(Cc1ccc(cc1)c2ccccc2c3nnn[nH]3)[C@@H](C(C)C)C(=O)O	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T0118	Type-1 angiotensin II receptor	antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID	27108902	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting XBP1S

Reference Record 2

PubMed ID	23762250	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	mice	Fibrosis Disease	Lacrimal gland fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	23762250	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	mice	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	23762250	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	22377232	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting HIF-1α pathway

Reference Record 6

PubMed ID	18787107	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	vitro,mice	Fibrosis Disease	Pancreatic fibrosis
Process I
Process II	cells proliferation,cells apoptosis
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	16893502	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III
Mechanism

Reference Record 8

PubMed ID	29312499	Target ID
Uniprot ID		Name
Model	rat	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Related Link

PubChem:	60846
ChEMBL:	CHEMBL1069