Givinostat

Basic Information

CAS ID: 497833-27-9
Molecular Formula: C24H27N3O4
Molecular Weight: 421.5 g/mol
Monoisotopic Mass: 421.2002 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

N O O NH O NH OH

Compound Structure and Identifier

InChI: InChI=1S/C24H27N3O4/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28) See All
InChI Key: YALNUENQHAQXEA-UHFFFAOYSA-N
Smiles: CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0974 Histone deacetylases inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 23552722 Target ID
Uniprot ID Name
Model mice Fibrosis Disease Muscle fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 26865052 Target ID T0974
Uniprot ID Histone deacetylases Name Histone deacetylases
Model vitro,rabbit Fibrosis Disease Corneal fibrosis
Process I
Process II fibroblasts differetiation,fibroblast migration
Process III prevenet collagen deposition
Mechanism Targeting TGFβ/BMP7 signaling pathway

Related Link

PubChem: 9804992
ChEMBL: CHEMBL1213492