DAPT

Basic Information

CAS ID: 208255-80-5
Molecular Formula: C23H26F2N2O4
Molecular Weight: 432.5 g/mol
Monoisotopic Mass: 432.1861 g/mol
Class: Small Molecule
Natural Product: No
Other Names:
Analysis: Drug repositioning mechanism analysis

NH O F F O NH O O

Compound Structure and Identifier

InChI: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1 See All
InChI Key: DWJXYEABWRJFSP-XOBRGWDASA-N
Smiles: C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H](C(=O)OC(C)(C)C)c2ccccc2 See All
Molfile: Download

Related Target

Target ID Name Interaction
T1016 Gamma secretase inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 26566963 Target ID T1016
Uniprot ID Gamma secretase Name Gamma secretase
Model vitro,human,rabbit Fibrosis Disease Scar
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 21450749 Target ID T1016
Uniprot ID Gamma secretase Name Gamma secretase
Model vitro Fibrosis Disease Systemic sclerosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting Notch signaling

Reference Record 3

PubMed ID 21312186 Target ID T1016
Uniprot ID Gamma secretase Name Gamma secretase
Model human,mice Fibrosis Disease Systemic sclerosis
Process I
Process II myofibroblasts differentiation
Process III prevenet collagen deposition
Mechanism Targeting Notch signaling

Related Link

PubChem: 5311272
ChEMBL: CHEMBL255682