Gamma secretase

Basic Information

Uniprot ID:
Secondary ID:
Symbol:
Other Name:
Class:	Protein Famliy
Type:	pro/anti-fibrotic
Molecular Function:

Target Classification

Category I	Category II	Category III
Other

Related Compound

Target ID	Name	Interaction
D0174	DAPT	inhibitor
D0253	Dibenzazepine	inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID	26566963	Compound ID	D0174
CAS	208255-80-5	Name	DAPT
Model	vitro,human,rabbit	Fibrosis Disease	Scar
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID	25150830	Compound ID	D0253
CAS	256-96-2	Name	Dibenzazepine
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II	myofibroblasts activation,fibroblasts proliferation,myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting TGF-β/Smad2/3 signaling

Reference Record 3

PubMed ID	21450749	Compound ID	D0174
CAS	208255-80-5	Name	DAPT
Model	vitro	Fibrosis Disease	Systemic sclerosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting Notch signaling

Reference Record 4

PubMed ID	21312186	Compound ID	D0174
CAS	208255-80-5	Name	DAPT
Model	human,mice	Fibrosis Disease	Systemic sclerosis
Process I
Process II	myofibroblasts differentiation
Process III	prevenet collagen deposition
Mechanism	Targeting Notch signaling

Reference Record 5

PubMed ID	29140985	Compound ID	D0253
CAS	256-96-2	Name	Dibenzazepine
Model	vitro,mice	Fibrosis Disease	Liver fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Notch signaling