Tubastatin A

Basic Information

CAS ID: 1252003-15-8
Molecular Formula: C20H21N3O2
Molecular Weight: 335.4 g/mol
Monoisotopic Mass: 335.1634 g/mol
Class: Small Molecule
Natural Product: No
Other Names: Tubastatin A
Analysis: Drug repositioning mechanism analysis

N N O NH OH

Compound Structure and Identifier

InChI: InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24) See All
InChI Key: GOVYBPLHWIEHEJ-UHFFFAOYSA-N
Smiles: CN1CCc2c(C1)c3ccccc3n2Cc4ccc(cc4)C(=O)NO See All
Molfile: Download

Related Target

Target ID Name Interaction
T0678 Histone deacetylase 6 inhibitor

Related Fibrosis Property

Reference Record 1

PubMed ID 25921924 Target ID T0678
Uniprot ID Histone deacetylase 6 Name Histone deacetylase 6
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 24434010 Target ID T0678
Uniprot ID Histone deacetylase 6 Name Histone deacetylase 6
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 29045477 Target ID T0678
Uniprot ID Histone deacetylase 6 Name Histone deacetylase 6
Model vitro,human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGFβ-PI3K-Akt pathway

Related Link

PubChem: 49850262
ChEMBL: CHEMBL2018302