Histone deacetylase 6

Basic Information

Uniprot ID: Q9UBN7
Secondary ID: O94975
Symbol: HDAC6
Other Name: KIAA0901
Class: Epigenetics
Type: pro-fibrotic
Molecular Function: Actin-binding,Chromatin regulator,Hydrolase,Repressor

Target Classification

Category I Category II Category III
Intracellular Epigenetics Eraser

Related Compound

Target ID Name Interaction
D0212 Tubastatin A inhibitor
D0277 Ricolinostat inhibitor
D0278 Tubacin inhibitor

Fibrosis Related Property

Reference Record 1

PubMed ID 28623308 Compound ID
CAS Name
Model vitro,mice Fibrosis Disease Cystic fibrosis
Process I
Process II
Process III
Mechanism

Reference Record 2

PubMed ID 25921924 Compound ID D0212
CAS 1252003-15-8 Name Tubastatin A
Model vitro,mice Fibrosis Disease Renal fibrosis
Process I attenue inflammation
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID 24434010 Compound ID D0277
CAS 1316214-52-4 Name Ricolinostat
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID 24434010 Compound ID D0212
CAS 1252003-15-8 Name Tubastatin A
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID 24434010 Compound ID D0278
CAS 537049-40-4 Name Tubacin
Model vitro Fibrosis Disease Liver fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID 18499657 Compound ID
CAS Name
Model vitro Fibrosis Disease Fibrosis
Process I
Process II EMT
Process III
Mechanism Taregeting SMAD3 signaling

Reference Record 7

PubMed ID 29045477 Compound ID D0212
CAS 1252003-15-8 Name Tubastatin A
Model vitro,human Fibrosis Disease Idiopathic pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism Targeting TGFβ-PI3K-Akt pathway