Candesartan

Basic Information

CAS ID:	139481-59-7
Molecular Formula:	C24H20N6O3
Molecular Weight:	440.5 g/mol
Monoisotopic Mass:	440.1597 g/mol
Class:	Small Molecule
Natural Product:	No
Other Names:	Candesartan \| CV-11974
Analysis:	Drug repositioning mechanism analysis

Compound Structure and Identifier

InChI:	InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)	See All
InChI Key:	HTQMVQVXFRQIKW-UHFFFAOYSA-N
Smiles:	CCOc1nc2cccc(C(=O)O)c2n1Cc3ccc(cc3)c4ccccc4c5nnn[nH]5	See All
Molfile:	Download

Related Target

Target ID	Name	Interaction
T0118	Type-1 angiotensin II receptor	antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID	25411386	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	vitro	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting β-catenin

Reference Record 2

PubMed ID	20719975	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Renal fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 3

PubMed ID	18313605	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rabbit	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	18055516	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	15097243	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 6

PubMed ID	12569276	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	vitro,rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 7

PubMed ID	11961044	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 8

PubMed ID	11961044	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 9

PubMed ID	11961044	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Cardiac fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Rho/ Rho-kinase and ERK/p70S6 kinase pathway

Reference Record 10

PubMed ID	11961044	Target ID	T0118
Uniprot ID	Type-1 angiotensin II receptor	Name	Type-1 angiotensin II receptor
Model	rat	Fibrosis Disease	Vascular fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting Rho/ Rho-kinase and ERK/p70S6 kinase pathway

Trial Record 1

ClinicalTrial ID	NCT00990639	Disease	Liver fibrosis
Phase	Phase 1,Phase 2	Status	Completed
First Received	October 7, 2009	Last Verified	October 7, 2009
Sponsor	Yonsei University

Related Link

PubChem:	2541
ChEMBL:	CHEMBL1016