Ketanserin

Basic Information

CAS ID: 74050-98-9
Molecular Formula: C22H22FN3O3
Molecular Weight: 395.4 g/mol
Monoisotopic Mass: 395.1645 g/mol
Class: Small Molecule
Natural Product: No
Other Names: R-41,468 | KETANSERIN | SUFREXAL | [3H]Ketanserin | Ketanserin Tartrate
Analysis: Drug repositioning mechanism analysis

F O N N O NH O

Compound Structure and Identifier

InChI: InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29) See All
InChI Key: FPCCSQOGAWCVBH-UHFFFAOYSA-N
Smiles: Fc1ccc(cc1)C(=O)C2CCN(CCN3C(=O)Nc4ccccc4C3=O)CC2 See All
Molfile: Download

Related Target

Target ID Name Interaction
T0145 5-hydroxytryptamine receptor 2A antagonist

Related Fibrosis Property

Reference Record 1

PubMed ID 18321937 Target ID T0145
Uniprot ID 5-hydroxytryptamine receptor 2A Name 5-hydroxytryptamine receptor 2A
Model human,mice Fibrosis Disease Pulmonary fibrosis
Process I
Process II
Process III prevenet collagen deposition
Mechanism

Reference Record 2

PubMed ID 25045122 Target ID T0145
Uniprot ID 5-hydroxytryptamine receptor 2A Name 5-hydroxytryptamine receptor 2A
Model vitro,rat Fibrosis Disease Biliary fibrosis
Process I
Process II cells proliferation
Process III prevenet collagen deposition
Mechanism Targeting TGF-β1 signaling

Related Link

PubChem: 3822
ChEMBL: CHEMBL51