5-hydroxytryptamine receptor 2A

Basic Information

Uniprot ID:	P28223
Secondary ID:	B2RAC5
Symbol:	HTR2A
Other Name:	HTR2,5-HT-2,5-HT-2A,Serotonin receptor 2A
Class:	Single Protein
Type:	pro-fibrotic
Molecular Function:	G-protein coupled receptor,Host cell receptor for virus entry,Receptor,Transducer

Target Classification

Category I	Category II	Category III
Extracellular	G protein-coupled receptor	Serotonin receptor

Related Compound

Target ID	Name	Interaction
D0011	Terguride	antagonist
D0257	Ketanserin	antagonist
D0366	Spiperone	antagonist
D0442	SB215505	antagonist
D0461	LY-53857	antagonist
D0462	Metitepine	antagonist
D0463	Ritanserin	antagonist
D0495	Sarpogrelate	antagonist

Fibrosis Related Property

Reference Record 1

PubMed ID	28821451	Compound ID	D0011
CAS	37686-84-3	Name	Terguride
Model	rat	Fibrosis Disease	Pulmonary fibrosis
Process I	attenue inflammation
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting TGF-β1 signaling

Reference Record 2

PubMed ID	25045122	Compound ID	D0257
CAS	74050-98-9	Name	Ketanserin
Model	vitro,rat	Fibrosis Disease	Biliary fibrosis
Process I
Process II	cells proliferation
Process III	prevenet collagen deposition
Mechanism	Targeting TGF-β1 signaling

Reference Record 3

PubMed ID	18321937	Compound ID	D0442
CAS	162100-15-4	Name	SB215505
Model	human,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 4

PubMed ID	18321937	Compound ID	D0257
CAS	74050-98-9	Name	Ketanserin
Model	human,mice	Fibrosis Disease	Pulmonary fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism

Reference Record 5

PubMed ID	16936262	Compound ID	D0366
CAS	749-02-0	Name	Spiperone
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,HSCs apoptosis
Process III
Mechanism

Reference Record 6

PubMed ID	16936262	Compound ID	D0461
CAS	60634-51-7	Name	LY-53857
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,HSCs apoptosis
Process III
Mechanism

Reference Record 7

PubMed ID	16936262	Compound ID	D0462
CAS	20229-30-5	Name	Metitepine
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation,HSCs apoptosis
Process III
Mechanism

Reference Record 8

PubMed ID	16936262	Compound ID	D0463
CAS	87051-43-2	Name	Ritanserin
Model	vitro	Fibrosis Disease	Liver fibrosis
Process I
Process II	HSCs proliferation
Process III
Mechanism

Reference Record 9

PubMed ID	24107419	Compound ID	D0495
CAS	125926-17-2	Name	Sarpogrelate
Model	vitro,mice	Fibrosis Disease	Renal fibrosis
Process I
Process II
Process III	prevenet collagen deposition
Mechanism	Targeting PAI-1